Table 2 Additional objectives for the CompARE trial

Qualitative Recruitment Investigation (QRI) objectives

1. To monitor recruitment rates and identify sources of recruitment difficulties in the first year of the trial

2. To develop a plan to optimise randomisation and informed consent

Health economics objectives

1. To compare cost-effectiveness in all treatment arms through cost-utility analysis

2. To estimate the cost per quality-adjusted life years (QALY) over the 2-year period of the trial

Translational research (CompARE Collect) objectives

1. To prospectively collect and ‘bank’ high-quality tissue, saliva, and blood samples from patients with intermediate- and high- risk OPC

2. To develop and validate biomarker classifiers to aid better stratification of treatment selection

3. To develop several inter-related and complementary head and neck translational research projects