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  1. Content type: Study protocol

    Existing data on physical rehabilitation interventions in critical illness are challenged by outcome heterogeneity that limits data synthesis and translation of research findings into clinical practice. This p...

    Authors: Bronwen Connolly, Linda Denehy, Nicholas Hart, Natalie Pattison, Paula Williamson and Bronagh Blackwood

    Citation: Trials 2018 19:294

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  2. Content type: Study protocol

    Despite the combination of surgical resection, radio- and chemotherapy, median survival of glioblastoma multiforme (GBM) patients only slightly increased in the last years. Disease recurrence is definite with ...

    Authors: Marion Rapp, Oliver M. Grauer, Marcel Kamp, Natalie Sevens, Nikola Zotz, Michael Sabel and Rüdiger V. Sorg

    Citation: Trials 2018 19:293

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  3. Content type: Study protocol

    The current randomized controlled trial seeks to evaluate whether providing access to an Internet intervention for problem drinking in addition to an Internet intervention for problem gambling is beneficial fo...

    Authors: John A. Cunningham, David C. Hodgins, Matthew Keough, Christian S. Hendershot, Kylie Bennett, Anthony Bennett and Alexandra Godinho

    Citation: Trials 2018 19:295

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  4. Content type: Study protocol

    Cardiac autonomic neuropathy is a commonly overlooked complication of type 2 diabetes mellitus (T2DM) characterized by an imbalance between sympathetic and parasympathetic supply to the heart, which contribute...

    Authors: Shalini Verma, Jamal Ali Moiz, Shahnawaz Anwer, Ahmad H. Alghadir and Mohammed Ejaz Hussain

    Citation: Trials 2018 19:289

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  5. Content type: Research

    The prevention of postoperative complications is of prime importance after complex elective abdominal operations. Preoperative patient education may prevent postoperative complications and improve patients’ we...

    Authors: Ulla Klaiber, Lisa M. Stephan-Paulsen, Thomas Bruckner, Gisela Müller, Silke Auer, Ingrid Farrenkopf, Christine Fink, Colette Dörr-Harim, Markus K. Diener, Markus W. Büchler and Phillip Knebel

    Citation: Trials 2018 19:288

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  6. Content type: Study protocol

    The cross-sectional area of the subclavian vein (csSCV) is an important factor determining the success rate of SCV catheterization. The head-down position increases the csSCV. However, the effects of lateral t...

    Authors: Dhong Eun Jung, Hyung-Chul Lee, Hyun-Kyu Yoon and Hee-Pyoung Park

    Citation: Trials 2018 19:292

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  7. Content type: Study protocol

    The teacher’s role in school mental health initiatives cannot be overemphasized. Despite global evidence of educational interventions in improving teachers’ knowledge and attitudes regarding mental health, thi...

    Authors: Nazish Imran, Atif Rahman, Nakhshab Chaudhry and Aftab Asif

    Citation: Trials 2018 19:290

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  8. Content type: Study protocol

    Urinary stone disease is very common with an estimated prevalence among the general population of 2–3%. Ureteric stones are associated with severe pain as they pass through the urinary tract and have significa...

    Authors: Samuel McClinton, Sarah Cameron, Kathryn Starr, Ruth Thomas, Graeme MacLennan, Alison McDonald, Thomas Lam, James N’Dow, Mary Kilonzo, Robert Pickard, Ken Anson, Frank Keeley, Neil Burgess, Charles Terry Clark, Sara MacLennan and John Norrie

    Citation: Trials 2018 19:286

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  9. Content type: Research

    For community interventions to be effective in real-world conditions, participants need to have sufficient exposure to the intervention. It is unclear how the dose and intensity of the intervention differ amon...

    Authors: Angela Cristina Bizzotto Trude, Anna Yevgenyevna Kharmats, Jessica C. Jones-Smith and Joel Gittelsohn

    Citation: Trials 2018 19:287

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  10. Content type: Study protocol

    Due to limited resources, waiting periods for psychotherapy are often long and burdening for those in need of treatment and the health care system. In order to bridge the gap between initial contact and the be...

    Authors: Sasha-Denise Grünzig, Harald Baumeister, Jürgen Bengel, David Ebert and Lena Krämer

    Citation: Trials 2018 19:285

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  11. Content type: Study protocol

    Type 2 diabetes mellitus (T2DM) and obesity are syndemic and will have a significant impact on affected individuals and healthcare services worldwide. Evidence shows that T2DM remission can be achieved with si...

    Authors: Shahrad Taheri, Odette Chagoury, Hadeel Zaghloul, Sara Elhadad, Salma Hayder Ahmed, Omar Omar, Sherryl Payra, Salma Ahmed, Neda El Khatib, Rasha Abou Amona, Katie El Nahas, Matthew Bolton, Henem Chaar, Noor Suleiman, Amin Jayyousi, Mahmoud Zirie…

    Citation: Trials 2018 19:284

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  12. Content type: Research

    Sharing interim results by the Data Safety Monitoring Board (DSMB) with non-DSMB members is an issue that can affect trial integrity. It is unclear what should be shared. This study assesses the views of profe...

    Authors: Victoria Borg Debono, Lawrence Mbuagbaw, James Paul, Norman Buckley and Lehana Thabane

    Citation: Trials 2018 19:281

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  13. Content type: Study protocol

    Process evaluations are critical for interpreting and understanding outcome trial results. By understanding how interventions function across different settings, process evaluations have the capacity to inform...

    Authors: Stephanie T. Jong, Helen Elizabeth Brown, Caroline H. D. Croxson, Paul Wilkinson, Kirsten L. Corder and Esther M. F. van Sluijs

    Citation: Trials 2018 19:282

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  14. Content type: Research

    Randomised controlled trials (RCTs) are challenging to conduct in a paediatric critical-care environment. Background work, including surveys and observational studies, is often used to determine disease estima...

    Authors: Anna Liu and Kusum Menon

    Citation: Trials 2018 19:283

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  15. Content type: Study protocol

    Over the last decade, a wide range of attention-deficit/hyperactivity disorder (ADHD) treatment approaches for adults, including both pharmacological interventions and psychosocial treatments, have been propos...

    Authors: Toivo Zinnow, Tobias Banaschewski, Andreas J. Fallgatter, Carolin Jenkner, Florence Philipp-Wiegmann, Alexandra Philipsen, Wolfgang Retz, Esther Sobanski, Johannes Thome and Michael Rösler

    Citation: Trials 2018 19:280

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  16. Content type: Study protocol

    Previous studies have shown that electroacupuncture (EA) reduces the severity of acute pancreatitis. However, the effect of EA for pain relief in patients with acute pancreatitis has not been evaluated yet. Th...

    Authors: Dong Kee Jang, Chan Yung Jung, Kyung Ho Kim and Jun Kyu Lee

    Citation: Trials 2018 19:279

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  17. Content type: Study protocol

    Mindfulness has been applied in the United States and Europe to improve physical and psychological health; however, little is known about its feasibility and efficacy in a Brazilian population. Mindfulness may...

    Authors: Vera Salvo, Jean Kristeller, Jesus Montero Marin, Adriana Sanudo, Bárbara Hatzlhoffer Lourenço, Mariana Cabral Schveitzer, Vania D’Almeida, Héctor Morillo, Suely Godoy Agostinho Gimeno, Javier Garcia-Campayo and Marcelo Demarzo

    Citation: Trials 2018 19:277

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  18. Content type: Study protocol

    Physical activity is associated with a lower risk of cognitive decline in older adults. However, past studies have demonstrated that older adults tend to relapse into inactivity after completing interventions....

    Authors: Songee Jung, Sungchul Lee, Seongryu Bae, Sangyoon Lee, Keitaro Makino, Yohei Shinkai and Hiroyuki Shimada

    Citation: Trials 2018 19:276

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  19. Content type: Study protocol

    Enhanced mobility in the Intensive Care Unit (ICU) could minimize the negative effects of critical illness, such as declines in cognitive, muscular, respiratory, and functional capacity. We aim to compare the ...

    Authors: Debora Stripari Schujmann, Adriana Claudia Lunardi and Carolina Fu

    Citation: Trials 2018 19:274

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  20. Content type: Review

    Trials in rare diseases have many challenges, among which are the need to set up multiple sites in different countries to achieve recruitment targets and the divergent landscape of clinical trial regulations i...

    Authors: Rebecca A. Crow, Kimberly A. Hart, Michael P. McDermott, Rabi Tawil, William B. Martens, Barbara E. Herr, Elaine McColl, Jennifer Wilkinson, Janbernd Kirschner, Wendy M. King, Michele Eagle, Mary W. Brown, Deborah Hirtz, Hanns Lochmuller, Volker Straub, Emma Ciafaloni…

    Citation: Trials 2018 19:291

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  21. Content type: Study protocol

    Post-stroke depression (PSD) is the most common psychiatric complication after a stroke. The most frequently used antidepressants are selective serotonin receptor inhibitors (SSRIs) and serotonin and norepinep...

    Authors: Ai-mei Zhao, Wen-ran Qiu, Li-jun Mao, Jun-guo Ren, Li Xu, Ming-jiang Yao, Kellie Bilinksi, Dennis Chang and Jian-xun Liu

    Citation: Trials 2018 19:275

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  22. Content type: Study protocol

    Evidence for benefit of high positive end-expiratory pressure (PEEP) is largely lacking for invasively ventilated, critically ill patients with uninjured lungs. We hypothesize that ventilation with low PEEP is...

    Authors: Anna Geke Algera, Luigi Pisani, Dennis C. J. Bergmans, Sylvia den Boer, Corianne A. J. de Borgie, Frank H. Bosch, Karina Bruin, Thomas G. Cherpanath, Rogier M. Determann, Arjen M. Dondorp, Dave A. Dongelmans, Henrik Endeman, Jasper J. Haringman, Janneke Horn, Nicole P. Juffermans, David M. van Meenen…

    Citation: Trials 2018 19:272

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  23. Content type: Study protocol

    Postoperative morbidity and mortality in patients undergoing surgery is high, especially in patients who are at risk of complications and undergoing major surgery. We hypothesize that perioperative, algorithm-...

    Authors: Sandra Funcke, Bernd Saugel, Christian Koch, Dagmar Schulte, Thomas Zajonz, Michael Sander, Angelo Gratarola, Lorenzo Ball, Paolo Pelosi, Savino Spadaro, Riccardo Ragazzi, Carlo Alberto Volta, Thomas Mencke, Amelie Zitzmann, Benedikt Neukirch, Gonzalo Azparren…

    Citation: Trials 2018 19:273

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  24. Content type: Study protocol

    Dementia has a huge physical, psychological, social and economic impact upon caregivers, families and societies at large. There has been a growing impetus to utilize Internet interventions given the potential ...

    Authors: Kala M. Mehta, Dolores Gallagher-Thompson, Mathew Varghese, Santosh Loganathan, Upasana Baruah, Katrin Seeher, Diana Zandi, Tarun Dua and Anne Margriet Pot

    Citation: Trials 2018 19:271

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