Fig. 1From: Initial treatment with a single capsule containing half-dose quadruple therapy versus standard-dose dual therapy in hypertensive patients (QUADUAL): statistical analysis plan for a randomized, blinded, crossover trialFlow diagram of the QUADUAL trial. A Angiotensin receptor blocker (irbesartan 150 mg). B Beta-blocker (metoprolol 47.5 mg). C Calcium channel blocker (amlodipine 5 mg). D Diuretic (indapamide 2.5 mg)Back to article page