Table 2 Description of the AHSCT treatment interventions
| Â | Original trial design | Patient-oriented trial design |
|---|---|---|
Years after treatment without further scleroderma organ damage | 1–10 years | 1–10 years |
Members of the care team | Extended medical team: rheumatologist, hematologist, cardiologist, respirologist, nurse | Multidisciplinary care: extended medical team + allied health professionals to provide mental, wellbeing and nutritional support |
Immediate complication | Low dose chemotherapy and full body irradiation; risk of complications which could lead to death: 5% (5 in 100) | Low dose chemotherapy and full body irradiation; risk of complications which could lead to death: 5% (5 in 100) |
Late complications | Risk of late complication from treatment (e.g., cancer) in the future: 20% (20 in 100) | Risk of late complication from treatment (e.g., cancer) in the future: 20% (20 in 100) |
Hematologist’s experience | 5 or more patients | 5 or more patients |
Additional cost to you | $1000–$5000 | $0 to $1000 |
Distance of the treatment center from your home | More than 1000 km | Between 50 and 300 km |