Visit/week number | Screening | Baseline (week 0) | 4 | 8 | 12 | 16 | 20 | 24 |
---|---|---|---|---|---|---|---|---|
Informed consent | x | Â | Â | Â | Â | Â | Â | Â |
Knee x-ray | x | Â | Â | Â | Â | Â | Â | Â |
Knee MRI | x* | Â | Â | Â | Â | Â | Â | x |
Clinical measures | ||||||||
 Bloods | x |  |  |  | x |  |  | x |
 Clinical examination | x |  |  |  |  |  |  |  |
 Leg strength |  | x |  |  | x |  |  | x |
 Height and weight |  | x |  |  |  |  |  | x |
 Capsules given |  | x |  |  | x |  |  |  |
 Capsule count |  |  |  |  | x |  |  | x |
 Pressure pain testing (Melbourne/Perth only) |  | x |  |  | x |  |  | x |
 Ultrasound (Perth) |  | x |  |  |  |  |  | x |
Questionnaire measures | Â | Â | Â | |||||
 Knee VAS | x | x | x | x | x | x | x | x |
 Knee WOMAC |  | x | x | x | x | x | x | x |
 Knee ICOAP |  | x | x | x | x | x | x | x |
 Patient global evaluation |  | x | x | x | x | x | x | x |
 Joint replacement surgery | x |  |  |  | x |  |  | x |
 Concomitant medications | x |  |  |  | x |  |  | x |
 Safety (AEs) |  |  |  |  | x |  |  | x |
 Hand VAS, back VAS |  | x | x | x | x | x | x | x |
 AQoL |  | x |  |  | x |  |  | x |
 Patient health questionnaire (PHQ-9) |  | x |  |  |  |  |  |  |
 Pain at other sites |  | x |  |  | x |  |  | x |
 Treatment guessing |  |  |  |  | x |  |  | x |
 painDETECT |  | x |  |  |  |  |  |  |
 Adverse events | As required | |||||||
 Early withdrawal | As required |