Inclusion criteria | Exclusion criteria |
---|---|
a. Definitive diagnosis of MS confirmed by a neurologist | a. Depression (BDI >4 and meeting criteria of depression as assessed by MINI) |
b. Severely fatigued (CIS20r fatigue ≥35) | b. Primary sleep disorders (anamnesis) |
c. Age between 18 and 70 | c. Severe co-morbidity (CIRS item ≥3) |
d. Ambulatory patients (EDSS ≤6) | d. Current pregnancy or having given birth in the past 3 months |
e. No evident signs of an exacerbation, or corticosteroid treatment in the past three months | e. Pharmacological treatment for fatigue that was started in the past 3 months |
f. No current infections (anamnesis) | f. Non-pharmacological therapies for fatigue that took place in the last 3 months |
g. No anaemia (anamnesis) | g. Receiving CBT in the TREFAMS-CBT trial |
h. A normal thyroid function (anamnesis) |