Fig. 1
From: Project management lessons learned from the multicentre CYCLE pilot randomized controlled trial
CYCLE pilot RCT schema. Participants were randomized within the first 4 days of mechanical ventilation (MV) to either 30 min of cycling plus routine physiotherapy or routine physiotherapy alone. Physical performance measures were collected at 3 time points: ICU awakening (Test #1), ICU discharge (Test #2), and hospital discharge (Test #3). Physical performance measures included manual muscle testing, the 30-s sit-to-stand test, the 2-min walk test, quadriceps femoris strength measured with a hand-held dynamometer, and the PFIT-s. The PFIT-s at hospital discharge was the primary outcome