N at baseline | N after 1st intervention | N after 2nd intervention | Baseline | APAP compared with baseline | NOT compared with baseline | NOT compared with APAP | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean | SD | Mean difference | Lower 95% CI | Upper 95% CI | Mean difference | Lower 95% CI | Upper 95% CI | Mean difference | Lower 95% CI | Upper 95% CI | ||||
Heart rate | 21 | 20 | 19 | 76 | 27 | 3.2 | 0.1 | 7.0 | −0.6 | −11.0 | 7.0 | 0.3 | −2.3 | 3.4 |
Respiratory rate | 21 | 20 | 19 | 17.9 | 2.0 | −0.2 | −0.6 | 0.2 | −0.2 | −1.4 | 0.5 | −0.1 | −1.0 | 0.6 |
Systolic blood pressure | 21 | 20 | 19 | 120 | 13 | −1.9 | −5.2 | 1.3 | −1.7 | −5.1 | 1.6 | 0.5 | −2.0 | 3.2 |
Diastolic blood pressure | 21 | 20 | 19 | 63.6 | 10.6 | 2.0 | −0.2 | 4.4 | 1.6 | −0.9 | 3.9 | −0.3 | −2.6 | 1.9 |
Mean arterial blood pressure | 21 | 20 | 19 | 100.9 | 11.2 | 0.7 | −1.2 | 2.7 | 0.5 | −1.5 | 2.3 | 0 | −1.8 | 1.6 |
Pulse pressure | 21 | 20 | 19 | 56.0 | 12.2 | 4.0 | −0.4 | 8.3 | −3.2 | −6.9 | 0.9 | 0.8 | −2.7 | 4.2 |
Daytime oxygen saturation | 21 | 20 | 19 | 97.7 | 1.2 | 0.2 | −0.3 | 0.6 | 0.3 | −0.1 | 0.6 | 2.6 | 0.4 | 5.0 |
White blood cell count | 21 | 21 | 20 | 9.6 | 3.0 | 1.0 | −0.4 | 2.6 | 0.1 | −0.8 | 0.9 | −1.0 | −2.8 | 0.5 |
Haemoglobin | 21 | 21 | 20 | 86.6 | 13.1 | −3.2 | −6.0 | −0.2 | −2.5 | −4.6 | 0.3 | 1.1 | −1.2 | 3.6 |
Red cell count | 21 | 21 | 20 | 2.9 | 0.7 | −0.2 | −0.3 | 0 | −0.1 | −0.2 | 0 | 0.1 | −0.02 | 0.2 |
Absolute reticulocytes | 20 | 20 | 19 | 194 | 77 | −23.8 | −78.8 | 21.3 | −31.1 | −70.3 | 0.5 | −16.7 | −51.2 | 19.3 |
Lactate dehydrogenase | 19 | 16 | 17 | 505 | 150 | 20.6 | −15.6 | 56.6 | 3.8 | −35.9 | 42.5 | 12.1 | −16.2 | 42.1 |
Alanine transferase | 19 | 15 | 17 | 32 | 38 | 5.6 | 0.3 | 12.8 | 6.4 | 0.9 | 17.4 | −1.6 | −7.5 | 4.0 |
Erythropoietin | 16 | 13 | 10 | 99 | 68 | −20.0 | −63.3 | 31.1 | −27.5 | −62.0 | 2.6 | −4.2 | −29.7 | 21.3 |
Creatinine | 20 | 19 | 18 | 57.4 | 16.7 | 0.5 | −2.9 | 4.3 | 2.1 | −0.9 | 5.3 | 1.3 | −0.2 | 4.7 |
Bilirubin | 21 | 19 | 19 | 50 | 42 | 3.0 | −2.8 | 9.1 | −1.3 | −7.1 | 3.8 | −2.0 | −6.9 | 2.6 |
Albumin creatinine ratio | 10 | 9 | 9 | 2.6 | 2.2 | −1.5 | −5.3 | 0.5 | −1.3 | −4.2 | 0.3 | −0.2 | −1.4 | 1.2 |
Vital capacity (L) | 10 | 9 | 9 | 3.7 | 0.9 | 0.1 | 0 | 0.2 | 0 | −0.1 | 0.1 | −0.1 | −0.2 | 0.1 |
Vital capacity (%) | 10 | 9 | 9 | 90.5 | 11.4 | 1.1 | −4.3 | 5.4 | −0.8 | −3.0 | 1.8 | −1.9 | −4.3 | 1.7 |
Functional residual capacity (L) | 10 | 9 | 9 | 3.0 | 0.6 | −0.1 | −0.3 | 0.1 | −0.1 | −0.2 | 0 | 0 | −0.1 | 0.1 |
Functional residual capacity (%) | 10 | 9 | 9 | 94.7 | 9.5 | −2.1 | −7.1 | 3.6 | −1.7 | −5.5 | 1.6 | 0.4 | −3.9 | 5.0 |
Inspiratory capacity (L) | 10 | 9 | 9 | 2.5 | 0.6 | −0.1 | −0.4 | 0 | −0.1 | 0.1 | 0.13 | 0.1 | −0.1 | 0.4 |
Total lung capacity (L) | 10 | 9 | 9 | 5.3 | 1.0 | −0.7 | −2.0 | 0.1 | −0.2 | −0.3 | 0 | 0.5 | −0.3 | 1.9 |
Total lung capacity (%) | 10 | 9 | 9 | 89.3 | 9.5 | −2.7 | −8.0 | 2.6 | −1.0 | −4.7 | 3.7 | 1.7 | −3.4 | 7.0 |
Residual volume (L) | 10 | 9 | 9 | 1.7 | 0.5 | −0.2 | −0.4 | 0 | −0.1 | −0.3 | 0.2 | 0.1 | −0.1 | 0.4 |
Residual volume (%) | 10 | 9 | 9 | 105 | 33 | −15.6 | −30.2 | −0.9 | −3.3 | −15.0 | 11.0 | 12.2 | −2.1 | 25.4 |
Residual volume:total lung capacity (L) | 10 | 9 | 9 | 32.1 | 8.5 | −2.4 | −6.2 | 2.1 | −8.4 | −24.7 | 2.1 | −6.0 | −24.7 | 4.9 |
Forced vital capacity (FVC) over 1 s | 10 | 9 | 9 | 3.7 | 1.0 | 0.19 | 0 | 0.5 | 0.1 | −0.1 | 0.4 | −0.1 | −0.2 | 0 |
Forced expiratory volume (FEV) over 1 s | 10 | 9 | 9 | 2.9 | 0.7 | 0 | 0 | 0.1 | 0 | 0 | 0.1 | 0 | −0.1 | 0 |
FEV over 1 s (%) | 10 | 9 | 9 | 84.0 | 10.3 | 0.4 | −3.2 | 3.1 | −0.6 | −3.1 | 2.0 | −1.0 | −2.9 | 0.6 |
FEV:FVC (%) | 10 | 9 | 9 | 82.7 | 11.8 | −1.4 | −5.2 | 2.1 | 2.8 | −0.1 | 7.3 | 4.2 | −0.3 | 9.3 |
Forced expiratory flow (FEF) 25–75% (L/s) | 10 | 9 | 9 | 3.6 | 1.3 | −0.4 | −1.0 | 0.2 | −0.2 | −1.5 | 1.4 | 0.2 | −1.2 | 1.4 |
FEF 50% (L/s) | 10 | 9 | 9 | 3.6 | 1.1 | −0.2 | −0.5 | 0.1 | 0 | −0.3 | 0.2 | 0.1 | −0.2 | 0.4 |
FEF 75% (L/s) | 10 | 9 | 9 | 2.9 | 2.5 | 2.5 | 1.0 | 4.3 | −0.3 | −1.2 | 0.2 | −2.8 | −4.5 | −1.2 |
Peak expiratory flow (L/min) | 10 | 9 | 9 | 433 | 72 | −102 | −218 | −2.6 | −69.7 | −169 | 23.8 | 32.3 | −32.9 | 138 |
Daytime oxygen saturation during LFTs (%) | 10 | 9 | 9 | 93.9 | 2.7 | 0.3 | −2.9 | 3.6 | 0.1 | −2.3 | 2.1 | −0.1 | −1.9 | 1.7 |