Table 2 Antifungal therapy depending on (1,3)-β-D-glucan concentrations
Diagnostic results | Recommendation |
|---|---|
(1,3)-β-D-glucan < 80 pg/ml in both measurements | No initial antifungal therapy |
• No Candida spp. in blood culture or other primary sterile body fluids | No antifungal therapy |
• Candida spp. proven in blood culture or other primary sterile body fluids | Start antifungal therapy according to European guidelines |
(1,3)-β-D-glucan ≥ 80 pg/ml in one of two measurements | Immediately start antifungal therapy for ICI according to European guidelines [16] |
• No Candida spp. in blood culture or other primary sterile body fluids | Antifungal therapy is discontinued |
• Candida spp. proven in blood culture or other primary sterile body fluids | Antifungal therapy is continued |
(1,3)-β-D-glucan ≥ 80 pg/ml in both measurements | Immediately start antifungal therapy for ICI according to European guidelines [16] |
• No Candida spp. in blood culture or other primary sterile body fluids | Antifungal therapy is continued |
• Candida spp. proven in blood culture or other primary sterile body fluids | Antifungal therapy is continued |