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Table 4 Estimates for the absolute risk reduction expected in the ABC PICU trial

From: The age of blood in pediatric intensive care units (ABC PICU): study protocol for a randomized controlled trial

 

Analytic cohort study: Gauvin et al. [1]

Descriptive cohort study: Karam et al. [2]

Storage time cutoff for “fresh” RBC unit

7 days

7 days

PICU expected length of stay

> 24 h

> 48 h

Hemodynamically unstable patients

No

Yes

NPMODS in transfused patients

15%

39.2%

Odds ratio for development of NPMODS in older versus fresher (confidence interval)

1.39 (0.42–4.61)

1.54 (0.80–2.96)

Estimated risk in experimental group 1/OR = (p1/(1 − p1))/(p0/(1 − p0))

11%

22%

  1. MODS multiple organ dysfunction syndrome, NPMODS new or progressive multiple organ dysfunction syndrome, OR odds ratio, PICU pediatric intensive care unit, RBC red blood cell, RCT randomized controlled trial
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ISSN: 1745-6215