Inclusion criteria | |
1. Patient diagnosed with chronic persistent asthma | |
2. Annual uncontrollable time ≥ 3 months | |
3. Patients who have given written informed consent | |
Exclusion criteria | |
1. History of upper upper/lower respiratory infection in the previous 1Â month | |
2. History of long-term controller medication use for asthma (orally or intravenously administered corticosteroid therapy) within the preceding 1Â month | |
3. History of antibiotic use in the previous 1Â month | |
4. History of life-threatening asthma | |
5. History of chronic lung diseases | |
6. History of serious disease of the heart and cerebrovascular disease | |
7. History of severe liver or renal dysfunction or disease | |
8. History of severe disease in the hematopoietic system | |
9. History of immunodeficiency (including, but not limited to, HIV-positive detection) | |
10. History of any other condition (such as known drug or alcohol abuse or psychiatric disorder) | |
11. Are currently enrolled in, or discontinued within the last 30Â days from, a clinical trial involving an investigational product or non-approved use of a drug or device | |
12. History of allergies to the component of the investigational drugs | |
13. Smoking within the past year | |
14. Contraindication to induced sputum collection method on history or examination | |
15. Any serious medical condition which, in the opinion of the investigator, would pose a significant risk to the patient or interfere with the interpretation of safety, efficacy, or pharmacodynamic data |