Time point | Physical exam and medical history | Blood draw | Oral glucose tolerance test | Physical function testing (SPPB) | Body composition (DXA, CT, and circumferences) | Muscle biopsy | SF-36, PASE, PROMIS modules | Muscle strength and power testing (Biodex, 1RM) | 4-day diet record | Physical activity monitoring |
---|---|---|---|---|---|---|---|---|---|---|
Pre-treatment | X | X | X | X | X | X | X | Familiarization | X | X |
2 weeks of metformin or placebo treatment only (prior to progressive resistance training, PRT) | ||||||||||
Week 2 (pre-PRT) | X | X | X | |||||||
Week 4 | X | |||||||||
Week 9 (mid-PRT) | X (CMP only) | X | ||||||||
Week 16 (post-PRT) | X | X | X | X | X | X | X | X | X | |
Long-term follow-up (week 26 and week 52) | X | X | X | X |