Inclusion criteria: |
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Signed informed consent form |
Age ≥18 years |
Patients with chronic heart failure, as defined by the European Society of Cardiology (update 2016) |
New York Heart Association (NYHA) functional class II–IV |
Patients who require diuretic therapy for maintain euvolaemia |
Stable clinical condition during index hospitalization with established proper diuretic dosage |
Exclusion criteria: |
Acute coronary syndrome |
Hypertrophic cardiomyopathy |
Uncontrolled hypertension |
Uncontrolled diabetes |
Serum potassium >6.0 mmol/l |
Serum creatinine >2.5 mg/dl |
Malignancy |
Life expectancy <1 year |
Planned valve surgery or heart transplantation |