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Table 1 Effect of tranexamic acid (TXA) on death due to bleeding by time from injury to initiation of treatment

From: Tranexamic acid in bleeding trauma patients: an exploration of benefits and harms

Time to treatment (h)

TXA allocated

Placebo allocated

Risk ratio (95% CI)

≤1

198/3747 (5 · 3%)

286/3704 (7 · 7%)

0 · 68 (0 · 57–0 · 82)

>1 to ≤3

147/3037 (4 · 8%)

184/2996 (6 · 1%)

0 · 79 (0 · 64–0 · 97)

>3

144/3272 (4 · 4%)

103/3362 (3 · 1%)

1 · 44 (1 · 12–1 · 84)

  1. Interaction χ2 = 23 · 516, p < 0 · 0000