|  | Study period | |||||
---|---|---|---|---|---|---|---|
 | Enrolment and allocation | Post-allocation | Close-out | ||||
Timepoint (months) | Â | Surgery | Follow-up after surgery | ||||
 | 0 | 1 | 2.5 | 4 | 7 | 13 | 25 |
Enrolment: | Â | Â | Â | Â | Â | Â | Â |
 Eligibility screen | X |  |  |  |  |  |  |
 Informed consent | X |  |  |  |  |  |  |
 Allocation | X |  |  |  |  |  |  |
Interventions: | Â | Â | Â | Â | Â | Â | Â |
 MIE with cervical anastomosis |  | X |  |  |  |  |  |
 MIE with intrathoracic anastomosis |  | X |  |  |  |  |  |
Assessments: | Â | Â | Â | Â | Â | Â | Â |
 Baseline patient characteristics | X |  |  |  |  |  |  |
 Baseline tumour characteristics | X |  |  |  |  |  |  |
 QOL questionnaires | X |  | X | X | X | X | X |
 CE questionnaires | X |  |  | X | X | X | X |
 Postoperative outcome data |  | X |  |  |  |  |  |
 Pathology data |  | X |  |  |  |  |  |
 Functional recovery data |  | X | X | X | X | X | X |
 Oncologic follow-up data |  |  | X | X | X | X | X |