Inclusion criteria | |
1. Children newborn to 17 years and on any dose of any vasoactive infusion for between 1 to 6 h | |
Exclusion criteria | |
1. Known or suspected hypothalamic, pituitary, or adrenal disease | |
2. Currently receiving steroids for shock prior to randomization | |
3. Expected to have life support withdrawn | |
4. Premature infants (<38 weeks corrected gestational age) | |
5. Pregnancy | |
6. Post cardiac surgery | |
7. First dose of vasoactive infusion administered >24 h after PICU admission | |
8. No longer on vasoactive infusion at time of enrollment and/or expected to no longer be on vasoactive infusion at time first dose of study drug due | |
9. Primary cardiogenic shock suspected or proven | |
10. Spinal shock suspected or proven | |
11. Hemorrhagic or hypovolemic shock suspected or proven | |
12. Previously enrolled in STRIPES | |
13. Started on vasoactive infusion for reasons not related to shock | |
14. Physician refusal |