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Table 3 Response to invitation; entering pre-randomisation run-in phase; and randomised by age, sex, and Townsend Index (central register route only)

From: Cost-effective recruitment methods for a large randomised trial in people with diabetes: A Study of Cardiovascular Events iN Diabetes (ASCEND)

 

No. invited

Responded and willing to participatea (% of invited)

Entered run-in (% of invited)

Randomised (% of invited)

Percent of those entering run-in who are subsequently randomised

Age (years)b

 

<50

12,753

1,729 (14 %)

1,262 (10 %)

694 (5 %)

55 %

 

≥50, < 60

59,635

7,580 (13 %)

4,914 (8 %)

2,801 (5 %)

57 %

 

≥60, < 70

93,526

11,040 (12 %)

6,103 (7 %)

3,543 (4 %)

58 %

 

≥70

134,274

9,508 (7 %)

3,812 (3 %)

1,975 (1 %)

52 %

Sex

 

F

130,889

10,642 (8 %)

5,931 (5 %)

3,297 (3 %)

56 %

 

M

169,299

19,215 (11 %)

10,160 (6 %)

5,716 (3 %)

56 %

Townsend Indexc

 

< -3

64,054

7,635 (12 %)

4,649 (7 %)

2,781 (4 %)

60 %

 

≥ -3 < 0

100,057

10,544 (11 %)

6,022 (6 %)

3,467 (3 %)

58 %

 

≥0 < 2

47,597

4,207 (9 %)

2,179 (5 %)

1,201 (3 %)

55 %

 

≥2 < 4

41,932

3,576 (9 %)

1,697 (4 %)

838 (2 %)

49 %

 

≥4 < 6

30,637

2,466 (8 %)

1,009 (3 %)

496 (2 %)

49 %

 

≥6

15,354

1,287 (8 %)

458 (3 %)

195 (1 %)

43 %

Urban/rural locationd

 

Urban

244,718

23,729 (10 %)

12,590 (5 %)

6,960 (3 %)

55 %

 

Rural

54,116

5,923 (11 %)

3,397 (6 %)

2,004 (4 %)

59 %

 

Unknown

1,354

205 (15 %)

104 (8 %)

49 (4 %)

47 %

Total

  

300,188

29,857(10 %)

16,091 (5 %)

9,013 (3 %)

56 %

  1. aIncludes willing but ineligible responses. Eligibility likely to vary in subgroups due to differing incidence of prior vascular disease
  2. bBased on age on the date screening invitation generated
  3. cBased on postcode at screening (lower values indicate least deprived). Score unknown for 557 of those invited
  4. dBased on postcode at screening (using ONS 2011 Rural-Urban Classification for Small Area Geographies)