Table 1 Clinical trials comparing biologics, Triple Therapy and methotrexate
From: Making smart investment decisions in clinical research
Year | Biologic vs. MTX | Triple Therapy vs. MTX | Triple Therapy vs. biologic |
|---|---|---|---|
1996 | TRI > MTX | ||
1997 | |||
1998 | INF > MTX | ||
1999 | INF > MTX, ETN > MTX | TRI > MTX, TRI > MTX | |
2000 | ETN > MTX, INF > MTX, INF > MTX | ||
2001 | |||
2002 | ANA > MTX | TRI > MTX | |
2003 | ABA > MTX, ADA > MTX | ||
2004 | ANA > MTX, RIX > MTX, ADA > MTX, ETN > MTX, ETN > MTX, INF > MTX | ||
2005 | ABA > MTX, INF > MTX | ||
2006 | INF > MTX, ADA > MTX, RIT > MTX, RIT > MTX, ABA > MTX, TOC > MTX, INF > MTX, INF > MTX | ||
2007 | INF > MTX, ADA > MTX, ABA > MTX | ||
2008 | ADA > MTX, TOC > MTX, ETN > MTX, GOL > MTX, CER > MTX, INF > MTX, TOC > MTX | ||
2009 | ADA > MTX, ADA > MTX, GOL > MTX, TOC > MTX, CER > MTX, ABA > MTX | ||
2010 | RIT > MTX, TOC > MTX, ETN > MTX, GOL > MTX | ||
2011 | TOC > MTX | ||
2012 | CER > MTX, GOL > MTX | TRI ≈ ETN, TRI ≈ INF | |
2013 | ABA > MTX, ADA > MTX, ADA > MTX, ETN > MTX, | TRI ≈ ETN |