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Table 1 Patient eligibility criteria

From: TElmisartan in the management of abDominal aortic aneurYsm (TEDY): The study protocol for a randomized controlled trial

Inclusion criteria

• Written informed consent

• Infra-renal AAA with maximum orthogonal diameter of ≥35 mm and ≤49 mm on CTA or ultrasound

• No current indication for AAA repair, or expectation that this will be revised in 12 months

• Likely to comply with treatment over 24 months, including seven visits to study centre

Exclusion criteria

• Currently taking or likely to start taking an AT1 blocker

• Currently taking or likely to start taking an ACE inhibitor

• Previous abdominal aortic surgery

• Contraindication to telmisartan:

 o Renal impairment: creatinine >1.5 x ULN

 o Known renal artery stenosis >70 % of one or both renal arteries

 o Chronic liver disease (that is, cirrhosis or hepatitis) or abnormal liver function (that is, ALT > 1.5 x ULN)

 o Electrolyte imbalance

 o Active gout

  1. AAA, abdominal aortic aneurysm; ACE, angiotensin converting enzyme; ALT, alanine transaminase; AT1, angiotensin II receptor type 1; CTA, computed tomographic angiography; ULN, upper limit of normal
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ISSN: 1745-6215