Definitions | Clinical efficacy | Microbiological efficacy | Timeframe |
---|---|---|---|
Cure | Complete resolution of all signs and symptoms of pneumonia. | Eradication of the bacterium causing ventilator-associated pneumonia during the treatment. | At 28 days of follow-up. |
Failure | Persistence or progression of signs and symptoms. | Persistence of the bacterium causing ventilator-associated pneumonia during the treatment. | At 28 days of follow-up. |
Relapse or recurrence | Recurrence of signs, symptoms and/or new radiographic evidence of pneumonia after final treatment. | Recurrence of signs, symptoms or new radiographic evidences of pneumonia present in the last evaluation and isolation of the initial pathogen. | At 28 days of follow-up. |
At any time after treatment finalization to end of follow-up. |