- Paper Report
- Open Access
Lack of effect of HRT on stroke/TIA risk 'not surprising'
- Joanna Lyford1
© Biomed Central Ltd 2001
- Received: 14 March 2001
- Published: 18 October 2001
- Cerebrovascular disorders, hormones, stroke
A study was undertaken to determine whether Hormone replacement therapy (HRT) increases the risk of stroke or transient ischaemic attack (TIA) among postmenopausal women with established heart disease.
Approximately 5% of the group, had 165 strokes, of which 85% were ischemic, resulting in 26 deaths. There was no significant association between HRT and nonfatal stroke, fatal stroke, or TIA, with approximately 7% of women on HRT suffering a nonfatal or fatal stroke, compared with 5% on placebo. Researchers noted that independent predictors of stroke events included increasing age, hypertension, diabetes, current cigarette smoking, and atrial fibrillation. However, a 4% decrease in stroke risk for each unit increase in BMI was observed.
At total of 2763 women were randomly assigned conjugated to receive either equine estrogen or placebo. The primary clinical endpoints were stroke incidence and stroke death over a mean follow-up of 4.1 years.