- Paper Report
- Open Access
Major study finds no link between gum disease and CV risk
- Joanna Lyford1
© Biomed Central Ltd 2001
- Received: 15 March 2001
- Published: 18 October 2001
- Cardiovascular disease, periodental disease
Experts have speculated that oral bacterial infection could move into the systemic circulation and cause chronic inflammation and other proatherogenic processes. The present study set out to investigate whether people with peridontal disease have a greater risk of developing cardiovascular disease.
They found that self-reported histories of peridontal disease at baseline were not associated with increased risk of CHD an average of 12.3 years later. At follow-up, the investigators reported 797 nonfatal myocardial infarctions, 631 nonfatal strokes, and 614 cardiovascular deaths. For each endpoint, the study had >90% power to detect a clinically important increased risk of 50%. Even after adjusting for age and treatment assignment, those physicians who presented with peridontal disease at baseline had slightly elevated, but statistically nonsignificant, relative risks for all three conditions. Moreover, further adjustment for cigarette smoking and other possible CV risk factors reduced the estimates to the null value of 1.0.
The authors analyzed self-reported data on 22,071 middle-aged males participating in the Physicians' Health Study I (PHS I) in the USA.