| 3–6 months | 1 year | 2 years | 3 years | ||||
---|---|---|---|---|---|---|---|---|
Number of patients and change in alkaline | Â | Â | Â | Â | Â | Â | Â | Â |
phosphatase | Active | Placebo | Active | Placebo | Active | Placebo | Active | Placebo |
n | 694 | 721 | 558 | 595 | 444 | 473 | 360 | 362 |
Decrease ≥ 20% | 81.0 | 3.1 | 72.8 | 5.1 | 76.4 | 11.0 | 87.5 | 21.3 |
Decrease 0–20% | 15.9 | 44.1 | 21.7 | 37.2 | 19.4 | 40.9 | 8.9 | 43.2 |
Increase | 3.2 | 52.8 | 5.6 | 57.7 | 4.3 | 48.1 | 3.6 | 35.5 |