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Figure 1 | Trials

Figure 1

From: An approach to trial design and analysis in the era of non-proportional hazards of the treatment effect

Figure 1

Time-dependent outcome measures exemplified by the GOG111 trial in advanced ovarian cancer. (a) Kaplan-Meier curves (solid lines) and estimated survival functions (dashed lines) from a flexible parametric model; (b) difference in survival functions; (c) instantaneous hazard ratio; (d) difference in restricted mean survival time. Shaded areas are pointwise 95% confidence intervals. Estimates in panels (b), (c) and (d) are derived from a flexible parametric model.

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Trials

ISSN: 1745-6215