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Table 2 Parameter estimates following heterogeneous cluster merges: scenario 3 a

From: Changing cluster composition in cluster randomised controlled trials: design and analysis considerations

 

Number of cluster merges per treatment group

Empirical estimates

0

1

2

5

10

20

Assigned to control

      

Intercept, β0

0.001 (−0.003, 0.004)

0.004 (0.000, 0.007)

0.006 (0.002, 0.009)

0.015 (0.012, 0.019)

0.032 (0.029, 0.035)

0.057 (0.054, 0.060)

Treatment effect, β1

0.199 (0.195, 0.204)

0.197 (0.192, 0.202)

0.194 (0.189, 0.198)

0.186 (0.181, 0.190)

0.170 (0.165, 0.175)

0.001 (−0.003, 0.004)

σ b 2

0.051 (0.049, 0.052)

0.050 (0.049, 0.051)

0.049 (0.047, 0.0498)

0.048 (0.046, 0.049)

0.046 (0.045, 0.047)

0.039 (0.038, 0.040)

σ w 2

0.951 (0.948, 0.954)

0.951 (0.949, 0.954)

0.953 (0.951, 0.956)

0.953 (0.951, 0.956)

0.958 (0.955, 0.961)

0.969 (0.966, 0.971)

Intracluster correlation coefficient

0.050 (0.048, 0.051)

0.050 (0.049, 0.051)

0.049 (0.047, 0.0494)

0.048 (0.046, 0.049)

0.046 (0.044, 0.047)

0.039 (0.037, 0.040)

Empirical power

82.5%

79.0%

78.8%

74.3%

64.3%

46.9%

Assigned to intervention

      

Intercept, β0

0.002 (−0.002, 0.005)

−0.002 (−0.006, 0.001)

0.000 (−0.004, 0.003)

0.001 (−0.003, 0.005)

0.000 (−0.004, 0.004)

−0.003 (−0.008, 0.001)

Treatment effect, β1

0.201 (0.197, 0.206)

0.198 (0.194, 0.203)

0.192 (0.187, 0.196)

0.185 (0.180, 0.190)

0.166 (0.161, 0.171)

0.146 (0.141, 0.152)

σ b 2

0.050 (0.048, 0.051)

0.050 (0.048, 0.051)

0.049 (0.047, 0.0499)

0.047 (0.046, 0.049)

0.045 (0.043, 0.046)

0.039 (0.038, 0.040)

σ w 2

0.948 (0.946, 0.950)

0.950 (0.947, 0.952)

0.950 (0.948, 0.953)

0.956 (0.953, 0.958)

0.958 (0.956, 0.961)

0.968 (0.965, 0.970)

Intracluster correlation coefficient

0.049 (0.048, 0.051)

0.050 (0.048, 0.051)

0.049 (0.047, 0.0498)

0.047 (0.046, 0.048)

0.045 (0.043, 0.046)

0.039 (0.037, 0.040)

Empirical power

82.7%

80.7%

79.5%

72.9%

64.2%

45.1%

Dropped from analysis

      

Intercept, β0

0.001 (−0.003,0.004)

−0.002 (−0.006, 0.001)

−0.001 (−0.004, 0.003)

−0.004 (−0.007, −0.001)

−0.001 (−0.005, 0.003)

0.000 (−0.004, 0.005)

Treatment effect, β1

0.202 (0.197, 0.207)

0.201 (0.196, 0.206)

0.199 (0.194, 0.204)

0.202 (0.197, 0.207)

0.202 (0.196, 0.207)

0.198 (0.192, 0.205)

σ b 2

0.051 (0.049, 0.052)

0.050 (0.048, 0.051)

0.050 (0.048, 0.051)

0.049 (0.048, 0.051)

0.049 (0.047, 0.051)

0.050 (0.048, 0.051)

σ w 2

0.949 (0.947, 0.952)

0.951 (0.948, 0.953)

0.952 (0.950, 0.955)

0.950 (0.947, 0.953)

0.953 (0.950, 0.956)

0.950 (0.946, 0.953)

Intracluster correlation coefficient

0.051 (0.049, 0.052)

0.050 (0.048, 0.051)

0.050 (0.048, 0.051)

0.049 (0.048, 0.051)

0.049 (0.047, 0.0499)

0.049 (0.048, 0.051)

Empirical power

81.7%

81.0%

78.3%

77.6%

70.2%

53.1%

  1. aPatient outcomes are assumed to be unaffected by cluster merge, indicating that all treatments were finished prior to merge. Total of 80 clusters with 20 patients in each cluster prior to cluster merges. Data are mean (95% confidence interval). σ b 2 is the between-cluster variance and σ w 2 is the within-cluster variance.