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Systematic review of interventions to increase recruitment and retention of black, minority and ethnic patients into randomised controlled trials

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Recruitment into cancer trials has been an area of concern for numerous years. In 2000 the NHS plan sought to double the number of patients entering cancer trials within 3 years. This was achieved through the creation of the National Cancer Research Network in 2001. By 2004, approximately 10.9% of all cancer patients were entered into a trial. However, recruitment of Black, Minority and Ethnic (BME) patients into clinical trials has been reported to be under-represented compared to the split of ethnicity both within the reported incidence of disease and the reported total population. Mason found a two-fold under representation of South Asians within breast cancer trials (Mason et al, 2003).

In the USA, a significant under-representation of Hispanics, Blacks and Asians was found when comparing ethnic proportions recruited within oncology trials with existing cancer cases (Murthy et al, 2004). The under-representation of any patient group within a clinical trial, specifically an ethnic one, can bias trial results, and subsequent extrapolation into the general population.

A systematic literature review of interventions to improve the recruitment and retention of minority patients into clinical trials was conducted. The search intended to capture literature pre- and post the Race Relations Act Amendment (2000) and the USA National Institute of Health Revitalisation Act (1993).

Preliminary results of the review have revealed a paucity of published evidence from the UK, with the majority of the articles meeting the inclusion criteria originating from the USA. Final results will be presented.

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Correspondence to Gulnaz Iqbal.

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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Iqbal, G., Dunn, J. & Thorogood, M. Systematic review of interventions to increase recruitment and retention of black, minority and ethnic patients into randomised controlled trials. Trials 14, P83 (2013) doi:10.1186/1745-6215-14-S1-P83

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Keywords

  • Breast Cancer
  • Clinical Trial
  • Randomise Control Trial
  • Cancer Case
  • Trial Result

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