Table 1 PRECISE study medicine dosage
Week | Pregabalin (or placebo) dosage | Total daily dose |
|---|---|---|
Week 1 | 1 × 75 mg capsule, twice a day, for 7 days | 150 mg/day |
Week 2 | 2 × 75 mg capsule, twice a day, for 7 days | 300 mg/day |
Week 3 | 3 × 75 mg capsule, twice a day, for 7 days | 450 mg/day |
Weeks 4 to 7 | 4 × 75 mg capsule, twice a day, for 7 days, maintained over 4 weeks or until adequate improvement (0 or 1 out of 10 leg pain for 72 hours) | 600 mg/day |
Week 8 (or after reaching adequate improvement) | Gradual titration down to cessation, for example 2 × 75 mg capsule, twice a day, for 4 days, then 1 × 75 mg capsule, twice a day, for 3 days | 300 mg/day or 150 mg/day |