| Surrogate Trials (N=138) N (%) | Final Trials (N=132) N (%) | P-value a |
---|---|---|---|
Study outcome b | Â | Â | 0.006 c |
Positive | 49 (36) | 41 (31) | Â |
Negative | 5 (4) | 4 (3) | Â |
Neutral | 32 (23) | 65 (49) | Â |
Risk of bias | Â | Â | Â |
Statement of ITT | 95 (69) | 106 (80) | 0.031 |
Automated sequence generation | 82 (59) | 93 (70) | 0.058 |
Allocation concealment | 96 (70) | 97 (63) | 0.476 |
Blinding/Placebo | 72 (52) | 60 (45) | 0.27 |