Table 3 Estimated unadjusted treatment effects (odds ratio (OR) and p value) on 14 day mortality with different approaches taking into account between-centre differences
Approach | Model | OR unadjusted | P value tx effect |
|---|---|---|---|
-Uniform treatment effect over centres -No adjustment for between-centre differences | Fixed effect logistic regression | 1.22 | 0.00010 |
-Uniform treatment effect over centres -Adjustment for between-centre differences | Random effect logistic regression with random intercept | 1.24 | 0.00003 |
-Varying treatment effect over centres -Adjustment for between-centre differences | Random effect logistic regression with random slope | 1.22 (95% range: 1.17-1.26) | 0.00029 |