Homogenous study group | Blinding of outcome assessor for genotype | Blinding of outcome assessor for treatment | Blinding of laboratory assessor for outcome | Blinding of treatmen t provider (doctor) for genotype | Blinding of treatment treatment | Blinding of patients for treatment | Check to what extent blinding was successful | Registration of loss to follow-up | Random allocation (description of procedure) | Treatment allocation concealed | |
---|---|---|---|---|---|---|---|---|---|---|---|
Hernandez 2000 [25] | + | + | + | - | - | - | + | - | + | - | - |
Hingorani 1997 [26] | + | - | - | - | - | - | - | - | - | +/- | - |
Kventy 2000 [27] | +/- | - | - | - | - | + | + | - | + | - | - |
Meurice 2001 [28] | +/- | - | - | - | - | + | + | - | + | - | +/- |
Okamura 1999 [21] | - | - | - | - | - | - | - | - | + | - | - |
Okumura 2002 [29] | + | - | - | + | - | - | - | - | +/- | - | - |
Pedersen 1997 [30] | - | + | + | + | - | + | + | - | + | +/- | - |
Penno 1998 [23] | +/- | - | - | +/- | - | + | + | - | + | + | + |
Perna 1999 [24] | +/- | - | - | - | - | + | + | - | - | + | + |
Pinto1995 [31] | - | + | + | + | - | + | + | - | - | - | - |
Van Geel 2003 [22] | + | - | - | - | - | - | + | - | - | +/- | - |
Methods for dealing with missing values | Compliance checked | Analysis of CI | Control for possible clinical and other confounders between genotypes | Control of co- interventions that bear on outcome for each genotype | Per protocol analysis | Intention to treat analysis | |||||
Hernandez 2000 [25] | - | +/- | - | + | - | - | + | ||||
Hingorani 1997 [26] | +/- | - | - | + | - | +/- | - | ||||
Kventy 2000 [27] | - | - | - | - | - | - | - | ||||
Meurice 2001 [28] | + | + | - | - | + | + | + | ||||
Okamura1999 [21] | - | - | - | +/- | +/- | - | - | ||||
Okumura 2002 [29] | - | - | - | - | - | + | - | ||||
Pedersen 1997 [30] | - | +/- | +/- | - | - | +/- | - | ||||
Penno 1998 [23] | +/- | +/- | + | +/- | +/- | +/- | + | ||||
Perna 1999 [24] | - | - | - | +/- | - | - | + | ||||
Pinto 1995 [31] | - | + | - | - | - | +/- | + | ||||
Van Geel 2003 [22] | - | - | - | +/- | - | +/- | - |