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Effectiveness of a home-based re-injury prevention program on motor control, return to sport and recurrence rates after anterior cruciate ligament reconstruction: study protocol for a multicenter, single-blind, randomized controlled trial (PReP)
Trials volume 20, Article number: 495 (2019)
Although anterior cruciate ligament (ACL) tear-prevention programs may be effective in the (secondary) prevention of a subsequent ACL injury, little is known, yet, on their effectiveness and feasibility. This study assesses the effects and implementation capacity of a secondary preventive motor-control training (the Stop-X program) after ACL reconstruction.
Methods and design
A multicenter, single-blind, randomized controlled, prospective, superiority, two-arm design is adopted. Subsequent patients (18–35 years) with primary arthroscopic unilateral ACL reconstruction with autologous hamstring graft are enrolled. Postoperative guideline rehabilitation plus Classic follow-up treatment and guideline rehabilitation plus the Stop-X intervention will be compared. The onset of the Stop-X program as part of the postoperative follow-up treatment is individualized and function based. The participants must be released for the training components. The endpoint is the unrestricted return to sport (RTS) decision. Before (where applicable) reconstruction and after the clearance for the intervention (aimed at 4–8 months post surgery) until the unrestricted RTS decision (but at least until 12 months post surgery), all outcomes will be assessed once a month. Each participant is consequently measured at least five times to a maximum of 12 times. Twelve, 18 and 24 months after the surgery, follow-up-measurements and recurrence monitoring will follow. The primary outcome assessement (normalized knee-separation distance at the Drop Jump Screening Test (DJST)) is followed by the functional secondary outcomes assessements. The latter consist of quality assessments during simple (combined) balance side, balance front and single-leg hops for distance. All hop/jump tests are self-administered and filmed from the frontal view (3-m distance). All videos are transferred using safe big content transfer and subsequently (and blinded) expertly video-rated. Secondary outcomes are questionnaires on patient-reported knee function, kinesiophobia, RTS after ACL injury and training/therapy volume (frequency – intensity – type and time). All questionnaires are completed online using the participants’ pseudonym only.
Group allocation is executed randomly. The training intervention (Stop-X arm) consists of self-administered home-based exercises. The exercises are step-wise graduated and follow wound healing and functional restoration criteria. The training frequency for both arms is scheduled to be three times per week, each time for a 30 min duration. The program follows current (secondary) prevention guidelines.
Repeated measurements gain-score analyses using analyses of (co-)variance are performed for all outcomes.
German Clinical Trials Register, identification number DRKS00015313. Registered on 1 October 2018.
The risk of suffering from a subsequent anterior cruciate ligament (ACL) injury following ACL reconstruction is increased 10-fold in comparison to the first-incidence risk. A recurrence risk of 10–25% is specified in the current literature [1, 2]. Such re-injuries often occur in the first years following the surgery , in particular during, or shortly after, the successful return to sport (RTS). It is a major goal of the RTS process to lead an athlete back to training and competition without exhibiting an excessively high risk for a subsequent rupture . Important criteria to be fulfilled, beyond psychosocial readiness and (of course) morphological graft healing, are, particularly, the restoration of neuromuscular and motor function. More precisely, a combination of dynamic strength and jump landing tests have been shown as being predictive for a second ACL injury [4, 5]. Enhancing and, thus, restoring these functional abilities may consequently lead to a decrease in the re-injury risk . Beyond these quantitative measures, the quality of dynamic jumping and cutting maneuvers, in particular the avoidance of a dynamic valgus position, are crucial for a positive RTS decision based on functional criteria [7, 8]. Qualitative assessments are used only infrequently [7, 8]. Furthermore, their responsiveness to functional changes as well as predictive value for a subsequent ACL injury remains mostly unknown. A current systematic review with meta-analyses on biomechanics during single-leg landings concludes that both movement quality and performance of functional tasks should be examined as RTS tests . Irrespective of the evaluation goal or if they having been validated or not, RTS tests are commonly performed at one single assessment at the hypothetical end of the RTS process . Performing a series of measurements with the purpose of monitoring changes over time during the RTS process may be more promising .
As strength and dynamic motor-control capacities, in particular, are preventive for a re-injury [4, 5], they have to be targeted in recurrence prevention programs. Inadequate knee mechanics also result from trunk displacement and unequal limb loading ; thus, it is not sufficient to only target the knee joint. As an important surrogate of functional restoration of the knee and, likewise, not only triggered by the knee joint solely, avoiding a dynamic knee valgus may be crucial to prevent subsequent injury [11, 12]. Although contextual overlap between therapeutic and preventive programs (such as the described dynamic motor-control enhancement and avoidance of a dynamic knee valgus) exists, the therapeutic focus after ACL reconstruction should shift from therapy to recurrence prevention after a certain rehabilitation time. Several prevention programs exist and have been validated in terms of preventive effects on a primary ACL rupture incidence . Although theoretical evidence exists that such programs may be effective in the prevention of a subsequent ACL injury , their effectiveness for primary and, in particular, for secondary prophylaxis after successful ACL reconstruction, is still a matter of debate. Likewise, the implementation capacity of such programs into everyday training after the prescribed rehabilitation is unknown.
The aim of the study is to assess the effects and implementation capacity of a preventive approach (Stop-X program ) after ACL reconstruction. Effects on re-injury-related motor-control/function, re-injury rates and time to successful RTS form the focus of this study.
The null hypothesis is as follows: the Stop-X program, as part of the evidence-based care and rehabilitation after ACL rupture and reconstruction, is not systematically superior to standard rehabilitation in terms of its effects on neuromuscular function, re-injury rate risk and time until RTS success.
Methods and design
Study design, ethics and informed consent
A multicenter, single-blind, randomized controlled, superiority, two-arm trial will be adopted. The comparator arms are guideline rehabilitation plus Classic follow-up treatment versus guideline rehabilitation plus the Stop-X intervention.
Central ethical approval has been confirmed from the independent Ethics Committee of the Hessen Regional Medical Council (ref approval no. FF 104/2017) and we will not begin recruiting at other centers in the trial until local ethical approval has been obtained. The date of the central approval was 27 June 2018. The study was planned and is performed in agreement with the Declaration of Helsinki (Version Fortaleza 2013). The trial was registered in the German Clinical Trials Register (DRKS), registration number DRKS00015313 (DRKS, drks.de; 01. October 2018). All adverse events will be reported. Each participant signs an informed consent prior to study enrollment.
The primary outcome is the normalized knee-separation distance (%) during a standardized Drop Jump Screening Test (DJST).
Sample size determination
No study to retrieve the minimal clinical relevant change for the primary outcome DJST has been published. For the sample size calculation (G*Power version 3.1), we thus considered the values from an interventional randomized controlled trial (RCT) . The mean post-intervention value was 66.4% (standard deviation (SD) = 14.2%). Considering a target effect of Cohen’s d = 0.3 (= mean change of 0.3 × SD), a two-sided alpha-error level of 5% and beta-error level of = 50%; data from N = 174 (n = 87 per group) participants have to be analyzed to statistically find a between-group difference using gain-score analyses. Assuming a dropout-rate of 30%, a total of 250 (n = 125 per group) patients will be included.
Recruitment and screening
Potential participants are recruited by personal addressing through one of the center heads (physicians) during or after a scheduled visit. Following application of the inclusion and exclusion criteria, patients are approved by the physician in charge.
Inclusion and exclusion criteria:
Adults (aged at surgery from 18 to 35 years) with remaining anterior knee instability after acute unilateral ACL rupture and having passed, or being scheduled for, an arthroscopically applied, anatomic single reconstruction (< 3 months between rupture and reconstruction) with autologous hamstrings tendon, will be included. Only participants engaged in sport (self-reported) prior to the injury and with the aim to return to their previous sporting activity are included. Exclusion criteria for the multimodal assessment protocol are: (1) meniscus lesion > 2 cm, (2) cartilage lesion > International Cartilage Regeneration and Joint Preservation Society (ICRS) grade II, (3) previous musculoskeletal surgery of the uninvolved (contralateral) leg, (4) leg mal-alignment > 5°, (5) multi-ligament injury pattern, (6) postoperative re-injury, (7) acute or chronic inflammation of the musculoskeletal system or muscle soreness and (8) pregnancy.
Randomization procedure and blinding
After sequential inclusion, volunteers are block-randomized using a non-stratified, permuted block with varying length strategy (N = 15 blocks; patient distribution = 1:1 in each arm/group. Each study sites’ participants are randomized using the site-specific randomization lists; the randomization sequence is generated using a computer-based algorithm (www.randomisation.com). All assessors and study personnel other than one study coordinator (DN) are blinded to group allocation. Participants are told not to communicate their group allocation to other participants or study staff. All data assessed are processed and analyzed blinded to treatment allocation.
The onset of the Stop-X program, as a part of (where applicable) the pre-operative and/or the postoperative follow-up treatment, is individualized: a graduated, shared and criteria-based decision is underlying . The participants must be released for the training components by their treating orthopedic specialist and by their physiotherapists. Likewise, the athletes, themselves, must indicate their physiological readiness. It is aimed to commence the Stop-X program at a time 4 to 8 months post surgery (Fig. 1).
The end of the (scheduled) intervention is the unrestricted RTS decision (aimed at 12–18 months post surgery). After this time point, the participants may continue the intervention but no further functional assessments will be conducted. Before (where applicable) surgery and until the unrestricted RTS decision, but at least until 12 months post surgery, all outcomes are assessed once a month. Thus, each participant is measured at least five times to a maximum of 12 times. Twelve (12), 18 and 24 months post reconstruction, follow-up measurements and recurrence monitoring follow. For this purpose, all participants are contacted by means of a structured telephone interview (separate consent). Participants are then asked for potential subsequent ACL re-injuries and other complaints/injuries. All measurements, except the structured telephone interviews, are performed by self-administration. The measures consist of jump landing tasks (10 min duration) and a questionnaire battery (5 min duration). The DJST is followed by the functional secondary outcomes. The latter consists of quality assessments during simple (combined) balance side and front hops, as well as quantity (centimeters) assessments of single-leg hops for distance. All hop/jump tests are self-administered, filmed from the frontal view (3-m distance) using the participant’s own smartphone. Videos are than expert-rated using the blinded videos. This setup has been shown to be valid when compared to 3D motion-capture systems for the analyses of sagittal-plane knee angles . All videos are transferred using a safe big content transfer (PowerFolder Enterprise File Sync und Share; Düsseldorf; Germany). To assure blind assessment, only the participants’ pseudonym is used.
Secondary patient-reported outcomes are assessed questionnaire-based: knee function, kinesiophobia, RTS after ACL injury and training/therapy volume (frequency – intensity – type and time). All questionnaires are completed online at www.surveymonkey.de using the participant’s pseudonym.
Both the training and measurements are instructed and supervized by means of (online) control of training, outcome assessment adherence and correct execution.
Primary outcome – Drop Jump Screening Test
The DJST is a common RTS criteria with a predictive value on an ACL rupture [8, 16]. Following warm-up exercises, patients take a bipedal hip-width stance on a box with a 32-cm target height. A bipedal drop jump follows: frontal step – drop – reactive jump with the shortest possible ground contact time. The knee position is rated at three pre-defined points during this drop-jump cycle: (1) initial ground contact at the end of the drop from the box, (2) lowest point of the body’s center of gravity at the jump’s reversal point and (3) ground take-off when the feet leave the surface for the reactive vertical jump. At each of these points, the distance between (a), the hip joints and (b), the centres of the patella of the two knees are measured. The percentage of the knee distance in comparison to the hip distance was calculated to calculate the normalized knee distance. Knee-separation and hip distance is analyzed using the video-analysis software Kinovea (France). Three jumps are performed, the middle one to be further analyzed. This measurement setup and the subsequent analyses are highly inter-rater reliable (κ = .92; 95% confidence interval (CI) 0.829–0.969) and moderately intra-rater reliable (κ = .55; 95% CI 0.49–0.61) , respectively. In the same validation study, a sensitivity of 63% and a specificity of 83% for the classification of “high-risk” participants (index group identified by expert observers) of the DJST was found.
Secondary outcomes: quality and quantity of the functional hop and jump tests
For sagittal-plane jumping-quality rating, the single Balanced Front Hop Test  was chosen. Participants have to hop over a square on the floor with a 40 × 40-cm edge length with hands on their hips; the end position after landing must be kept for at least three continuous seconds. The frontal-plane jumping-quality rating is undertaken using the Balanced Side Hop Test ; the participants hop over laterally (to the direction of the test foot (right or left) ) the same square and, immediately after landing, a reactive hop back to the starting position is initiated. After each trial, the participants have, again, to maintain the controlled landing position for three consecutive seconds with their hands on their hips .
Three hops for each condition and leg (randomized order) are performed, the middle one for each condition and leg to be further analyzed. Quality rating criteria are (1) feet remain stable on the ground after landing, (2) knees remains in the sagittal plane during all movements and (3) the trunk remains in the sagittal plane during all movements .
The single-leg hop for distance (SLHD) assesses (the quantity of) dynamic balance and single-leg-jumping performance ability. The participants stand on one leg with the toes behind the rear line of the square. They then hop as far as possible and have to land in a controlled manner. The whole hop must be performed one-legged. Three successful hops per leg (randomized order) are performed; each leg’s best trial (in centimeters) is selected for further analysis. The measurement properties for the SLHD are excellent, reliability is ICC = 0.97 (CI 0.9–0.99) and the standard error of measurement is 3.5% . It is considered valid in terms (as a major part of a testing battery) of predicting a subsequent ACL injury [4, 5].
Secondary outcomes: self-reported data
All questionnaires will be used in their validated German translation.
The Return-to-Sport after ACL injury (RSI-ACL) questionnaire assesses a participants’ fear of loading their reconstructed knee during their main sporting activity. Ten 11-point Likert-scale questions are used, a total score value of > 56 indicates sufficient confidence for RTS . The sum score assessment is highly reliable (Cronbach’s alpha = 0.92)  and valid .
Further (self-reported) control variables to be used will be the Tegner and Lysholm score, International Knee Documentation Committee knee evaluation form (IKDC-2000), Knee injury and Osteoarthritis Outcome Score (KOOS), subscale activities of all daily living (ADL), injury history, demographics, pain, and task-specific fear of movement/re-injury (visual analog scale (VAS) 10 cm) and kinesiophobia (Tampa Scale of Kinesiophobia; TSK).
The Tegner and Lysholm score  contains a 0–10-point Likert scale to assess a participant’s activity level, scaled from low-level daily living activity to high-level competitive sports level. Scoring is from 0 = low-level activity regarding knee loading, up to and including 10 = highest possible level of activity regarding knee loading. The Lysholm knee scoring scale rates symptoms and function during ADLs using eight scales to build a 0–100-point sum score. Test-retest reliability was found to be sufficient . The IKDC-2000 uses 18 items across three subdomains to assess: symptoms, sports activities and function. Differently graded Likert scales are used. Test-retest reliability is high, whereas the internal consistency and cross-cultural validity are unknown . The KOOS subscale ADL is one of five KOOS subdomains and must be scored from 0 to 4. Test-retest reliability was found to be high . The TSK uses 11 items across the domain “fear of movement/(re-)injury”; it is scored using 4-point Likert scales. Internal consistency and structural validity were found to be sufficient .
By means of a structured telephone interview, the time/date of the consensus, evidence-based, shared, positive return-to-play decision and potential re-injuries/complications/adverse effects are inquired. Further, the participants will be asked on their individual implementation capacity (barriers and chances) using a non-structured survey.
The training interventions (in particular the Stop-X arm) consist of self-administered home-based exercises which are step-wise graduated and follow wound-healing and functional restoration criteria. The training frequency for both arms is scheduled to be three times per week. A duration of 30 min is aimed for each session. The program follows current (secondary) prevention guidelines [24,25,26]. The program (in German) can be found online (pdf): http://deutsche-kniegesellschaft.de/wp-content/uploads/2017/02/DKG_Stop-X_Prävention-von-Sportverletzungen-am-Kniegelenk.pdf (permanent link, status 10/5/18) and (video description): https://stop-x.de/(permanent link, status 10/5/18). Details on the two training schemes (Stop-X versus Classic) are displayed in Table 1. All aspects of the training are divided into the wound-healing phases and the therapy goal. All similarities of and differences between the Classic and Stop-X exercise regimens are displayed.
All participants receive detailed information on the intervention scheduled. Classic intervention participants receive a standard follow-up scheme with defined key points; the Stop-X participants receive the same Classic intervention scheme and, additionally, the detailed information in terms of information material and specific instructions (print material and links) for the Stop-X program. All participants discuss their program with the therapy team (physiotherapists, athletic trainer).
To monitor home-training accuracy and compliance, all patients fill in an exercise log during the home-based training (online). Frequency, intensity, type and time of the exercises are reported in a standardized procedure. Likewise, all functional/exercise measures beyond the scheduled training are reported. Using the 14-step Likert scale of Borg rates of perceived exhaustion (6 = extremely light intensity; 20 = extremely vigorous), the intensity of the exercises is further rated.
Following range plausibility control based on potentially reachable physiological values, a visual control for non-plausible outliers will be performed. Afterwards, all analyses will be performed based on the underlying assumptions for parametric, or rather, non-parametric testing. In detail, for all difference testing, data and variance distribution (i.e., normality) are checked; for all correlation analyses, residuals, auto correlation, and heteroscedasticity, are checked. The alpha-error threshold is set at 5%, all p values below are considered significant.
The analyses for the primary outcome, DJST, are done confirmatory, alpha-error corrections (Bonferroni-Holm for paired and Sidak-Holm for unpaired analyses) are performed for multiple used samples and post-hoc analyses following significant omnibus testing, whilst the alpha-error remains unadjusted for the exploratory (secondary) analyses.
The main statistics are performed twice (two different data structures): once on a time-based and once on a functional-based data structure. All repeated measures statistics are thus first performed for the time-based data structure where statistics are performed on all outcomes assessed at the same real-time after reconstruction. Secondly, functional-based data-structure analyses are performed, where the first (baseline) measurement is the first “real” measurement at the time of being cleared for the assessment (varying times of 4–8 months post reconstruction). For each of the analyses on the two datasets, gain-score analyses are performed for differences from pre (baseline) to post (each following time point) of all outcomes using repeated-measures analyses of co-variance (rmANCOVAs) with potential confounders as co-variates (baseline values, injury history, sex, type and amount of sport, age, co-morbidities). In case of a systematic impact of confounders on statistics, z-transformed values are calculated and used for further analyses. Afterwards, survival analyses by means of Kaplan-Meier plotting plus between group-difference analyses using log-rank tests are performed. Hazard ratio estimations will be calculated. Events will be: (1) Time point of unrestricted RTS decision, (2) Time point of functional criterion RTS succeeded (> 60% normalized knee-separation distance at DJST) and (3) Time point of revision surgery, re-injury or subsequent injury.
All statistical analyses are performed using SPSS (SPSS Inc., IBM, Chicago, IL, USA) and BiAS (BiAS for Windows, Frankfurt, Germany).
The primary aim of the study is to test the feasibility and effectiveness of an ACL secondary preventive intervention. To do so, a standardized diagnostic assessment and a randomized controlled, single-blind intervention design are used. The intervention consists of exercises to target deficits in motor control and dynamic knee axis steadiness. A strength of this intervention is its practicability. Furthermore, all exercises can be performed without (or only with a little) additional material.
Recurrence prevention and the according diagnostics during and after RTS following ACL reconstruction are, except in professional athletes, only adopted to a minor degree . Even in professional sports, the athletes’ performance quality is decreased after return to competition  and the re-injury risk remains high for years after the ACL rupture [1, 2]. Consequently, and applicable in entire populations, developing and employing strategies for secondary prevention and appropriately adapted functional diagnostics are crucial. Beyond the focus on recurrence prevention, the potential of the program in pre-operative training may be given. Pre-operative training strategies are highlighted to be of importance , yet, they are only carried out sparsely; therefore, a feasible intervention may be helpful.
The heterogeneity of the participants may become a limitation for the results’ interpretation and the deduction of the practical relevance of our trial. To minimize this potential bias, co-variate analyses are performed. Together with the randomized study design and the resulting respect of unknown confounders, considering the known and suggested confounders provides a sufficient statistical power. A common limitation in clinical exercise trials is the limited possibility of blinding the patients. This limitation is reduced by the superiority design (no inactive control group) of our study. To further reduce the risk of bias as much as possible, all investigators are blinded to intervention allocation.
Beyond this, the results of our study will be of importance not only for researchers and policy makers, but also for patients.
Participant recruiting started on 25 October 2018. At the time of manuscript submission, we included six participants into the study. No participant has yet completed the intervention. Screening completion is anticipated to be 15 October 2019, measurement completion by 15 October 2020 and overall study completion is expected to be May 2021.
Availability of data and materials
Anterior cruciate ligament
Activities of daily living
Drop Jump Screening Test
German Clinical Trials Register
International Knee Documentation Committee knee evaluation form
Knee injury and Osteoarthritis Outcome Score
Return to sport
Single-leg hop for distance
Tampa Scale of Kinesiophobia
Niederer D, Engeroff T, Wilke J, Vogt L, Banzer W. Return to play, performance and career duration after ACL rupture: a case-control study in Europe’s biggest football nation. Scand J Med Sci Sports. 2018;28:2226–33. https://doi.org/10.1111/sms.13245 .
Wiggins AJ, Grandhi RK, Schneider DK, Stanfield D, Webster KE, Myer GD. Risk of secondary injury in younger athletes after anterior cruciate ligament reconstruction: a systematic review and meta-analysis. Am J Sports Med. 2016;44:1861–76. https://doi.org/10.1177/0363546515621554 .
Herring SA, Bergfeld JA, Boyd J. The team physician and return-to-play issues: a consensus statement. Med Sci Sports Exerc. 2002;34:1212–4.
Kyritsis P, Bahr R, Landreau P, Miladi R, Witvrouw E. Likelihood of ACL graft rupture: not meeting six clinical discharge criteria before return to sport is associated with a four times greater risk of rupture. Br J Sports Med. 2016;50:946–51. https://doi.org/10.1136/bjsports-2015-095908 .
Grindem H, Snyder-Mackler L, Moksnes H, Engebretsen L, Risberg MA. Simple decision rules can reduce reinjury risk by 84% after ACL reconstruction: The Delaware-Oslo ACL cohort study. Br J Sports Med. 2016;50:804–8. https://doi.org/10.1136/bjsports-2016-096031 .
Hewett TE, Di Stasi SL, Myer GD. Current concepts for injury prevention in athletes after anterior cruciate ligament reconstruction. Am J Sports Med. 2013;41:216–24. https://doi.org/10.1177/0363546512459638 .
Barber-Westin SD, Noyes FR. Factors used to determine return to unrestricted sports activities after anterior cruciate ligament reconstruction. Arthroscopy. 2011;27:1697–705. https://doi.org/10.1016/j.arthro.2011.09.009 .
Barber-Westin SD, Noyes FR. Objective criteria for return to athletics after anterior cruciate ligament reconstruction and subsequent reinjury rates: a systematic review. Phys Sportsmed. 2011;39:100–10. https://doi.org/10.3810/psm.2011.09.1926 .
Johnston PT, McClelland JA, Webster KE. Lower limb biomechanics during single-leg landings following anterior cruciate ligament reconstruction: a systematic review and meta-analysis. Sports Med. 2018;48:2103–26. https://doi.org/10.1007/s40279-018-0942-0 .
Dingenen B, Gokeler A. Optimization of the Return-to-Sport paradigm after anterior cruciate ligament reconstruction: a critical step back to move forward. Sports Med. 2017;47:1487–500. https://doi.org/10.1007/s40279-017-0674-6 .
Nessler T, Denney L, Sampley J. ACL injury prevention: what does research tell us? Curr Rev Musculoskelet Med. 2017;10:281–8. https://doi.org/10.1007/s12178-017-9416-5 .
Chimera NJ, Kremer K. Sportsmetrics training improves power and landing in high school rowers. Int J Sports Phys Ther. 2016;11:44–53.
Donnell-Fink LA, Klara K, Collins JE, Yang HY, Goczalk MG, Katz JN, Losina E. Effectiveness of knee injury and anterior cruciate ligament tear prevention programs: a meta-analysis. PLoS One. 2015;10:e0144063. https://doi.org/10.1371/journal.pone.0144063 .
Petersen W, Diermeier T, Mehl J, Stöhr A, Ellermann A, Müller P, et al. Prävention von Knieverletzungen und VKB-Rupturen - Empfehlungen des DKG Komitees Ligamentverletzungen: OUP; 2016. p. 542–50.
Finkbiner MJ, Gaina KM, McRandall MC, Wolf MM, Pardo VM, Reid K, et al. Video Movement Analysis using Smartphones (ViMAS): a pilot study. J Vis Exp. 2017. https://doi.org/10.3791/54659 .
Hewett TE. Anterior cruciate ligament injuries in female athletes: Part 2, A meta-analysis of neuromuscular interventions aimed at injury prevention. Am J Sports Med. 2005;34:490–8. https://doi.org/10.1177/0363546505282619 .
Redler LH, Watling JP, Dennis ER, Swart E, Ahmad CS. Reliability of a field-based drop vertical jump screening test for ACL injury risk assessment. Phys Sportsmed. 2016;44:46–52. https://doi.org/10.1080/00913847.2016.1131107 .
Keller M, Kurz E, Schmidtlein O, Welsch G, Anders C. Interdisziplinäre Beurteilungskriterien für die Rehabilitation nach Verletzungen an der unteren Extremität: Ein funktionsbasierter Return to Activity Algorithmus. Sportverletz Sportschaden. 2016;30:38–49. https://doi.org/10.1055/s-0042-100966 .
Kockum B, Heijne AI-LM. Hop performance and leg muscle power in athletes: reliability of a test battery. Phys Ther Sport. 2015;16:222–7. https://doi.org/10.1016/j.ptsp.2014.09.002 .
Gokeler A, Welling W, Zaffagnini S, Seil R, Padua D. Development of a test battery to enhance safe return to sports after anterior cruciate ligament reconstruction. Knee Surg Sports Traumatol Arthrosc. 2017;25:192–9. https://doi.org/10.1007/s00167-016-4246-3 .
Webster KE, Feller JA, Lambros C. Development and preliminary validation of a scale to measure the psychological impact of returning to sport following anterior cruciate ligament reconstruction surgery. Phys Ther Sport. 2008;9:9–15. https://doi.org/10.1016/j.ptsp.2007.09.003 .
Gagnier JJ, Shen Y, Huang H. Psychometric properties of Patient-Reported Outcome Measures for use in patients with anterior cruciate ligament injuries: a systematic review. JBJS Rev. 2018. https://doi.org/10.2106/JBJS.RVW.17.00114 .
Tegner Y, Lysholm J. Rating systems in the evaluation of knee ligament injuries. Clin Orthop Relat Res. 1985;198:43–9.
Petersen W, Stoffels T, Achtnich A. Prevention of knee injuries and ACL ruptures Systematic review and recommendations of the German Knee Society (DKG): The Stop-X program. Orthop J Sports Med. 2018;6:2325967118S0001. https://doi.org/10.1177/2325967118S00018 .
Stoffels T, Achtnich A, Petersen W. Prävention von Knieverletzungen – besteht da Evidenz? Sports Orthop Traumatol. 2017;33:344–52. https://doi.org/10.1016/j.orthtr.2017.09.005 .
Petersen W, Achtnich A, Diermeier T, Mehl J, Zantop T. Das instabile Kniegelenk: Diagnostik, Prävention und Therapie. Sports Orthop Traumatol. 2017;33:29–37. https://doi.org/10.1016/j.orthtr.2016.12.003 .
van Melick N, van Cingel REH, Brooijmans F, Neeter C, van Tienen T, Hullegie W, Nijhuis-van der Sanden MWG. Evidence-based clinical practice update: practice guidelines for anterior cruciate ligament rehabilitation based on a systematic review and multidisciplinary consensus. Br J Sports Med. 2016;50:1506–15. https://doi.org/10.1136/bjsports-2015-095898 .
Wilk KE, Arrigo CA. Rehabilitation principles of the anterior cruciate ligament reconstructed knee: twelve steps for successful progression and return to play. Clin Sports Med. 2017;36:189–232. https://doi.org/10.1016/j.csm.2016.08.012 .
Nyland J, Mattocks A, Kibbe S, Kalloub A, Greene JW, Caborn DNM. Anterior cruciate ligament reconstruction, rehabilitation, and return to play: 2015 update. Open Access J Sports Med. 2016;7:21–32. https://doi.org/10.2147/OAJSM.S72332 .
Niederer D, Wilke J, Vogt L, Banzer W. Return to play after injuries—A survey on the helpfulness of various forms of assistance in the shared decision-making process in semi-professional athletes in Germany. Arch Phys Med Rehabil. 2017:690–8. https://doi.org/10.1016/j.apmr.2017.10.019 .
Alshewaier S, Yeowell G, Fatoye F. The effectiveness of pre-operative exercise physiotherapy rehabilitation on the outcomes of treatment following anterior cruciate ligament injury: a systematic review. Clin Rehabil. 2017;31:34–44. https://doi.org/10.1177/0269215516628617.
The study is supported by a grant from the German Knee Society (DKG). We further prospectively thank both the technical and medical staff at the study sites for their investment during study conduction.
The study is supported by a grant from the German Knee Society (DKG).
Ethics approval and consent to participate
Final ethical approval has been provided on 27 June 2018. (number FF104/2017). Clinical trial registration (registration date 1 October 2018) in the German Clinical Trials Register received the identification number DRKS00015313. All participants provided their informed consent.
Consent for publication
The authors declare that they have no competing interests.
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Study sites, local principal investigators and scientific responsibilities
PD Dr. Dr. Stein, Thomas, Department of Sporttraumatology, Knee, and Shoulder Surgery, Berufsgenossenschaftliche Unfallklinik Frankfurt am Main, Frankfurt am Main, Germany
Co-principal investigator, statistics:
Dr. Niederer, Daniel, Department of Sports Medicine, Goethe University Frankfurt, Frankfurt am Main, Germany
Prof. Dr. Dr. Banzer, Winfried, Department of Preventive and Sports Medicine, Institute for Occupational, Social and Environmental Medicine, Goethe University Frankfurt, Frankfurt, Germany
Keller, Matthias, OSINSTITUT, Munich, Germany
PD Dr. Achtnich, Andrea, Department for Orthopaedic Sports Medicine, Klinikum rechts der Isar, Munich, Germany
Dr. Akoto, Ralph, Chirurgisch-Traumatologisches Zentrum, Asklepios Klinik St. Georg, Hamburg, Germany
Prof. Dr. Ateschrang, Atesch, BG Trauma Center Tübingen, Eberhard Karls University Tübingen, Tübingen, Germany
Dr. Barié, Alexander, Clinic for Orthopedics and Trauma Surgery, Center for Orthopedics, Trauma Surgery and Spinal Cord Injury, Heidelberg University Hospital, Heidelberg, Germany
Dr. Best, Raymond, Department of Orthopaedic and Trauma Surgery, Sportsclinic Stuttgart,; Department of Orthopaedic Sportsmedicine, University of Tuebingen
Dr. Ellermann, Andree, Arcus Sportklinik, Pforzheim, Germany
Prof. Dr. Marzi, Ingo, Prof. Dr. Frank, Johannes, Department of Trauma, Hand, and Reconstructive Surgery, Goethe University Frankfurt, Frankfurt am Main, Germany
Prof. Dr. Herbort, Mirco, Department of Trauma, Hand and Reconstructive Surgery, University Hospital Muenster, Muenster, Germany
Prof. Dr. Höher, Jürgen, Sports Clinic Cologne at Cologne Merheim Medical Center, Cologne, University of Witten/Herdecke, Cologne, Germany
PD Dr. med. Daniel Guenther, Department of Orthopaedic Surgery, Trauma Surgery, and Sports Medicine, Cologne Merheim Medical Center, Witten/Herdecke University
Dr. Jung, Tobias M, Center for Musculoskeletal Surgery, Charité-University Medicine Berlin, Berlin, Germany
PD Dr. Krause, Matthias, Department of Trauma, Hand and Reconstructive Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
Prof. Dr. Müller, Peter E; Andreas Fischer, Department of Orthopedic Surgery, Physical Medicine and Rehabilitation, University Hospital, Ludwig-Maximilians-University (LMU), Munich, Germany
Prof. Dr. Petersen, Wolf, Klinik für Orthopädie und Unfallchirurgie, Berlin, Germany
Dr. Stoffels, Thomas, Department of Trauma and Orthopaedic Surgery, Unfallkrankenhaus Marzahn, Berlin, Germany
Dr. Stöhr, Amelie, Orthopedic Surgery Munich, Munich, Germany
Dr. Welsch, Frederic, Department of Sporttraumatology, Knee, and Shoulder Surgery, Berufsgenossenschaftliche Unfallklinik Frankfurt am Main, Frankfurt am Main, Germany
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Cite this article
Niederer, D., Keller, M., Achtnich, A. et al. Effectiveness of a home-based re-injury prevention program on motor control, return to sport and recurrence rates after anterior cruciate ligament reconstruction: study protocol for a multicenter, single-blind, randomized controlled trial (PReP). Trials 20, 495 (2019) doi:10.1186/s13063-019-3610-2
- Return to sports
- Return to play
- Motor control
- Secondary prevention
- Post treatment
- Functional outcome