1) HR-pOCT measurements | |
(1) Measurements in the second and third metacarpal bones and in the wrist joint • Changes from baseline in periarticular BMD • Changes from baseline in periarticular bone micro-architecture • Changes from baseline in the width of joint space • Changes from baseline in BMD at the rim of erosive lesions (2) Measurements in the tibial bone • Changes from baseline in BMD • Changes from baseline in bone micro-architecture | |
2) Magnetic resonance imaging measurements | |
• Changes from baseline in the extent of osteitis • Changes from baseline in the extent of bone erosion • Changes from baseline in synovitis score | |
3) Musculoskeletal ultrasound measurements | |
• Changes from baseline in synovitis score • Changes from baseline in the extent of bone erosion | |
4) X-ray measurements | |
• Changes from baseline in bone erosion score • Changes from baseline in joint space narrowing score • Changes from baseline in the modified total Sharp score | |
5) DXA measurements | |
• Changes from baseline in lumbar spine BMD • Changes from baseline in femoral BMD | |
6) Changes from baseline in bone/cartilage turnover markers | |
7) Changes from baseline in other biomarkers | |
8) Changes from baseline in DAS28 |