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Table 1 Summary statistics on outcome reporting discrepancies

From: COMPare: a prospective cohort study correcting and monitoring 58 misreported trials in real time

 

Journal name

Annals

BMJ

JAMA

Lancet

NEJM

Total

Basic information

Number of trials included

5

3

13

24

22

67

Journal listed as “endorsing CONSORT”

Yes

Yes

Yes

Yes

Yes

All

Protocol availability

Pre-trial protocol with pre-specified outcomes available?

0

0

7

3

19

29

Percentage of pre-trial protocols available

0.0%

0.0%

53.9%

12.5%

86.4%

43.3%

Missing primary outcomes

Trials with any unreported primary outcomes

4

2

2

4

1

13

Percentage of trials with any unreported primary outcomes

80.0%

66.7%

15.4%

16.7%

5.0%

19.4%

Primary outcomes

Total number of primary outcomes pre-specified

9

4

22

34

28

97

Number of primary outcomes correctly reported as primary outcomes

4

1

18

24

27

74

Percentage of primary outcomes correctly reported

44.4%

25.0%

81.8%

70.6%

96.4%

76.3%

Number of primary outcomes reported anywhere

7

1

18

24

28

78

Percentage of primary outcomes reported anywhere

77.8%

25.0%

81.8%

70.6%

100.0%

80.4%

Secondary outcomes

Total number of secondary outcomes pre-specified

49

36

111

218

404

818

Number of secondary outcomes correctly reported as secondary outcomes

15

26

78

141

190

450

Percentage of secondary outcomes correctly reported

30.6%

72.2%

70.3%

64.7%

47.0%

55.0%

Number of secondary outcomes reported anywhere

15

26

78

142

190

451

Percentage of secondary outcomes reported anywhere

30.6%

72.2%

70.2%

65.1%

47.0%

55.1%

Novel outcomes

Number of novel outcomes reported without declaration

32

25

53

192

63

365

Mean number of novel outcomes reported without declaration, per trial

6.4

8.3

4.1

8

2.9

5.4

(95% CI 1.2–10.6)

Percentage of novel outcomes declared as novel

5.9%

0%

39.1%

9.4%

3.1%

13.7%

(95% CI 0.0–42.5%)

  1. Abbreviations: BMJ British Medical Journal, CI confidence interval, CONSORT Consolidated Standards of Reporting Trials, JAMA Journal of the American Medical Association, NEJM New England Journal of Medicine