Clinical (A) | Radiological/laboratory (B) |
---|---|
• Cough or cervical neck mass (≥2 × 2 cm) for > 2 weeks despite a course of antibiotics • Fever or lethargy for > 1 week despite a course of antibiotics • Documented failure to thrive, i.e. flattening of weight curve crossing centiles, documented weight loss, e.g. > 5%, moderate or severe malnutrition (Weight-for-height Z score < − 2) in relation to previous measures • Classic gibbus suggestive of spinal TB • Depressed level of consciousness, new onset seizures or focal neurological signs suggestive of TB meningitis | • AFBs or caseating granulomas on microscopy (not confirmed by culture or Xpert to be TB) • CXR suggestive of TB (concurrence between two blinded CXR reviewers, with conflicts resolved by third reviewer) despite a course of antibiotics • CSF suggestive of TB (white cell count 10-500 cells per µl with a lymphocyte predominance, protein > 1 g/dL, glucose < 2.2 mmol/L) • Pleural aspirate or ascitic tap with WBC counts, protein, and glucose levels suggestive of TB, consider ADA • CT brain suggestive of CNS TB |