Fig. 3
Relationship between statistical significance and clinical significance in superiority randomized controlled trials (RCTs). aTwo randomized questions included where the confidence interval of the treatment effect was based on an alpha of 0.05 although the sample size calculation stated an alpha of 0.10. This was due to insufficient information being reported which precluded calculating the 90% confidence interval. bStatistically significant solely due to the direction of the direction of the effect being related to harm as opposed to benefit