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Table 4 Pre-treatment schedule and parameters examined

From: Total thyroidectomy (Tx) versus thionamides (antithyroid drugs) in patients with moderate-to-severe Graves’ ophthalmopathy – a 1-year follow-up: study protocol for a randomized controlled trial

 

Initial screening until randomization

 

Day 1 (initial screening)

Day 2 (4–8 weeks after day 1)

Day 3 (4–8 weeks after day 2)

Day 4 (4–8 weeks after ATD reduction)

Day 5 (12–16 weeks after ATD reduction)

Day 6 (20–24 weeks after ATD reduction

Pregnancy test

X

X

X

X

X

X

Randomization and treatment

Blood tests

X

X

X

X

X

X

Slit-lamp bimicroscopy

X

    

X

Indirect fundoscopy

X

    

X

Visual acuity determination with Snellen test

X

    

X

Hertel exophthalmometry

X

    

X

Ocular motility, cover test, prism cover test, convergence

X

    

X

CAScore/NOSPECS

X

    

X

Ultrasound

     

X

Adverse events

 

X

X

X

X

X

Quality of life form

X

     

Case report form

X

X

X

X

X

X

Blood parameter form

X

X

X

X

X

X

Current medication form

X

X

X

X

X

X

Eye examination form

X

    

X

  1. Legend: ATD antithyroid drugs, CAScore Clinical Activity Score, NOSPECS No signs/symptoms, Only signs/no symptoms, Soft tissue involvement, Proptosis, Extraocular muscle involvement, Corneal involvement, Sight loss
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Trials

ISSN: 1745-6215