Table 1 Patient eligibility criteria

Female, at least 19 years old

Patients with a history of receiving chemotherapy for cancer before this diagnosis was made

Patients diagnosed with primary breast cancer

Patients with symptoms of peripheral neuropathy that are severe and need to be immediately treated with surgical procedures or acute management

Patients with a diagnosis of CIPN presenting within the first week of an average pain score of at least 5 on a visual analogue scale of pain after completion of chemotherapy

Patients with pre-existing peripheral neuropathy due to trauma or intercurrent illness

Patients who do not take any medication to prevent or treat neuropathy before screening

Patients with skin inflammation at the attachment site

Patients with an ECOG performance status of 2 or less

Patients with a history of previous use of an acupressure wristband over a week.

Patients with a history of cardiovascular disorders including the use of a pacemaker

Patients who are willing and able to comply with the requirements of the study

Patients with known hypersensitivity to metal or any medication

Patients who are willing and able to provide written informed consent

Patients with uncontrolled hypertension (systolic blood pressure ≥ 170 mmHg or diastolic blood pressure ≥ 100 mmHg) or uncontrolled diabetes

Patients with hepatic insufficiency or dysfunction (three times higher than normal levels of ALT, AST, creatinine)

Patients who were pregnant or are potentially pregnant and breastfeeding

Patients with psychiatric disorders or who take medication for psychiatric illnesses

Patients with a history of receiving investigative, new drugs within 4 weeks before enrollment

Patients who do not have the ability to read, understand, or respond to questionnaires

Patients with other reasons not to comply with this study protocol