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Table 1 Characteristics of clinical trials published in the 10 highest-impact US medical specialty society journals between 1 January 2010 and 31 December 2015 (N = 486)

From: Adherence to the International Committee of Medical Journal Editors’ (ICMJE) prospective registration policy and implications for outcome integrity: a cross-sectional analysis of trials published in high-impact specialty society journals

 

Number

Percentage

Interventiona

 Drug

287

59.1

 Device

46

9.5

 Vaccine or biological

86

17.7

 Other

102

21.0

Phaseb

 Phase II

190

39.1

 Phase III

110

22.6

 Phase IV

46

9.5

 Not listed

153

31.5

Randomization

 Yes

372

76.5

 No

114

23.5

Fundingc, d

 Industry

216

44.4

 Non-industry

270

55.6

Enrollment

  ≥ 100

280

57.6

  < 100

206

42.4

Location(s)

 US only

166

34.2

 US and international

84

17.3

 International only

236

48.6

Trial registrye

 ClinicalTrials.gov

383

87.2

 EU-CTR

76

17.3

 ISRCTN

24

5.5

 Other registriesf

47

10.7

  1. aClinical trials may have involved more than one intervention type
  2. b13 trials were designated as phase II/phase III
  3. cFunding information was not reported in the publications of 5 trials, all of which were unregistered; these trials were designated as not reporting industry funding
  4. dIndustry funding includes partial or full support
  5. e439 trials were registered. Percentages are expressed based on a denominator of 439. 81 trials were registered in multiple registries, hence percentages may not sum to 100
  6. f“Other registries” includes: Australia New Zealand Clinical Trials Register (ANZCTR), Chinese Clinical Trial Registry (ChiCTR), Clinical Trial Registry of India (CTRI), German Clinical Trials Register (DRKS), Japan Pharmaceutical Information Center Clinical Trials Information (JAPIC-CTI), Netherlands Trial Register (NTR), University Hospital Medical Information Network (UMIN) (a Japanese registry)
  7. Abbreviations: EU-CTR European Union Clinical Trials Register, ISRCTN International Standard Randomized Controlled Trial Network