Evaluation of the clinical effectiveness of bioactive glass (S53P4) in the treatment of non-unions of the tibia and femur: study protocol of a randomized controlled non-inferiority trial

Table 1 Structure of clinical and radiological follow-up

	Pre-op	2 D post-op	6 W post-op	3 M post-op	6 M post-op	9 M post-op	12 M post-op	24 M post-op
Clinical examination	x	x	x	x	x	x	x	x
X-ray	x	x	x	x	x	x	x	x
DCE-MRI				x
CT							x
CEUS	x			x
Questionnaire (SF-12)	x			x			x	x
Laboratory work	x	x	x	x	x	x	x	x

Abbreviations: pre-op pre-operative, post-op post-operative, D days, W weeks, M months, DCE-MRI dynamic contrast-enhanced MRI, CT computer tomography, CEUS contrast-enhanced ultrasound, SF-12 12-item Short Form health survey

ISSN: 1745-6215