Inclusion criteria | Exclusion criteria |
---|---|
> 18 years old at screening | Allergy/sensitivity to naloxone |
Presenting for elective major open hepatopancreaticobiliary resection under general anaesthetic | Female subjects who are pregnant or breast feeding |
Able/willing to give written informed consent and to comply with the requirements of the study | Received any other investigational medicine within the prior 2Â months |
 | Receiving anticonvulsant medications |
 | Cardiac arrhythmia with uncontrolled rate |
 | History of chronic opioid use/chronic pain |
 | Contraindication to intrathecal injection |
 | Documented history of obstructive sleep apnoea |
 | Treating clinician does not have equipoise to randomise this patient into the study |