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Table 2 Summary of outcomes categorised according to the COMET taxonomy

From: SCORE-IT (Selecting Core Outcomes for Randomised Effectiveness trials In Type 2 diabetes): a systematic review of registered trials

Core area Core domains Trials including one or more outcome in core domain (n (%)) Outcomes included in core domain (n (%)) Trials including as a primary outcomea (n)
Death Mortality/survival 3 (2.2) 3 (0.2) 0
Physiological/clinical Blood and lymphatic system outcomes 9 (6.5) 19 (1.3) 1
Cardiac outcomes 20 (14.5) 56 (3.9) 9
Congenital, familial and genetic outcomes 0(0) 0 (0)  
Endocrine outcomes 31(22.5) 50 (3.5) 7
Ear and labyrinth outcomes 0 (0) 0 (0) 0
Eye outcomes 2 (1.4) 2 (0.1) 0
Gastrointestinal outcomes 5 (3.6) 20 (1.4) 2
General outcomes 65 (47.1) 146 (10.1) 3
Hepatobiliary outcomes 12 (8.7) 25 (1.7) 3
Immune system outcomes 28 (20.3) 73 (5.1) 4
Infection and infestation outcomes 4 (2.9) 8 (0.6) 0
Injury and poisoning outcomes 0 (0) 0 (0) 0
Metabolism and nutrition outcomes 121 (87.7) 582 (40.3) 92
Musculoskeletal and connective tissue outcomes 2 (1.4) 2 (0.1) 1
Outcomes relating to neoplasms: benign, malignant and unspecified (including cysts and polyps) 0 (0) 0 (0) 0
Nervous system outcomes 6 (4.3) 16 (1.1) 2
Pregnancy, puerperium and perinatal outcomes 0 (0) 0 (0) 0
Renal and urinary outcomes 27 (19.6) 76 (5.3) 5
Reproductive system and breast outcomes 0 (0) 0 (0) 0
Psychiatric outcomes 2 (1.4) 2 (0.1) 0
Respiratory, thoracic and mediastinal outcomes 3 (2.2) 11 (0.8) 1
Skin and subcutaneous tissue outcomes 1 (0.7) 1 (0.1) 0
Vascular outcomes 51 (37) 134 (9.3) 13
Physical functioning 5 (3.6) 7 (0.5) 0
Life impact Social functioning 5 (3.6) 6 (0.4) 0
Role functioning 3 (2.2) 6 (0.4) 0
Emotional functioning/wellbeing 8 (5.8) 28 (1.9) 0
Cognitive functioning 2 (1.4) 22 (1.5) 0
Global quality of life 4 (2.9) 5 (0.3) 0
Perceived health status 4 (2.9) 4 (0.3) 0
Delivery of care 30 (21.7) 60 (4.2) 4
  Personal circumstance 0 (0) 0 (0) 0
Resource use Economic 4 (4) 6 (0.4) 0
Hospital 3 (2.2) 4 (0.3) 0
Need for intervention 16 (11.6) 24 (1.7) 1
Societal/carer burden 0 (0) 0 (0) 0
Adverse events Adverse events/effects 33 (23.9) 46 (3.2) 5
  1. aSome trials included more than one primary outcome