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Table 3 Outcomes and other measures of the medication management and education intervention

From: Patient-oriented education and medication management intervention for people with decompensated cirrhosis: study protocol for a randomized controlled trial

Categories/variables

Measure

Collection week

Medication discrepancies

 Between drug name and dosage

 Frequency of per-patient discrepancies

 Severity of discrepancies

Patient interview

Questionnaire

Medical record review

t 0, t 3

Medication-related problems (intervention arm only)

  

 Adverse drug reaction

 Drug interaction

 Untreated, undertreated, or overtreated indication

 Other medication-related barriers

Patient interview

Questionnaire

t 0, t 3

Adherence

 Self-reported medication adherence

 Affordability

MMAS-8

Patient interview

t 0, t 3

Quality of life

  

 Health-related quality of life

 Abdominal and systemic symptoms

 Emotional functioning, fatigue, and worry

 Daily activity

CLDQ

Brief IPQ

t 0, t 3

Beliefs and perceptions

 General medication beliefs

 Beliefs about liver disease medications

 Illness perceptions

BMQ-General

BMQ-Specific

Brief IPQ

t 0, t 3

Knowledge/health literacy

 Knowledge of causation

 Dietary modification including sodium restriction

 Self-monitoring requirements

 Safe analgesia

 Source of medication-related information

Questionnaire

Brief IPQ

t 0, t 3

Hospitalization

 Liver-related hospitalization

 Non-liver-related hospitalization

 Duration of stay

Medical record review

t 3, t 4

(and 3 years)

Survival

 Liver-related mortality

 Non-liver-related mortality

Medical record review

t 3, t 4

(and 3 years)

Cost

 Cost of service implementation

 Potential cost savings

Cost modeling

After study completion

  1. Abbreviations: BMQ Beliefs about Medicines Questionnaire, Brief IPQ Brief Illness Perception Questionnaire, CLDQ Chronic Liver Disease Questionnaire, MMAS-8 Eight-question Morisky Medication Adherence Scale