From: PANSAID – PAracetamol and NSAID in combination: study protocol for a randomised trial
Study | Intervention | Number of patients | Surgery | Pain | Opioid | Adverse events |
---|---|---|---|---|---|---|
Derry 2013 [7] | Paracetamol and ibuprofen vs. ibuprofen | 1647 (3 trials) | Extraction of at least 3 impacted third molars | Ibuprofen 200 mg and paracetamol 500 mg vs. placebo: NNT 1.6 (1.5–1.8) Ibuprofen 400 mg and paracetamol 1000 mg vs. placebo: NNT 1.5 (1.4–1.7) Ibuprofen 400 mg and paracetamol 1000 mg vs. ibuprofen 400 mg: NNT 5.4 (3.5–12.2) | Time to rescue medication: Ibuprofen 200 mg and paracetamol 500 mg: 7.6 h Ibuprofen 400 mg and paracetamol 1000 mg: 8.3 h Placebo: 1.7 h | No information |
Ong 2010 [20] | Combinations of paracetamol and various NSAIDs vs. 1 of these drugs | 1909 (21 trials) | Mixed surgical populations | Paracetamol and NSAID vs. paracetamol: 85% of studies showed that the combination had better analgesic properties than paracetamol alone Paracetamol and NSAID vs. NSAID: 64% of these studies showed that the combination had better analgesic properties than NSAID alone | Reduction in opioid consumption is not quantified in a combined measure | No systematic information |