| Study period | ||||
---|---|---|---|---|---|
Enrolment | Post-allocation | Close-out | |||
Timepoint | Diagnosed with breakthrough pain | Breakthrough pain episode (T0) | 5 min after starting intervention (T1) | 15 min after starting intervention (T2) | 5 min after finishing intervention (T3) |
Enrolment | |||||
 Eligibility screen | √ |  |  |  |  |
 Informed consent | √ |  |  |  |  |
 Allocation | √ |  |  |  |  |
Interventions | |||||
 Control group |  |  | √ | √ |  |
 Treatment groups |  |  | √ | √ |  |
Assessments | |||||
 Numerical pain rating scale |  | √ | √ | √ | √ |
 Blood pressure |  | √ | √ | √ | √ |
 Oxygen saturation |  | √ | √ | √ | √ |
 Heart rate |  | √ | √ | √ | √ |
 Satisfaction |  |  |  |  | √ |
 Side effect |  |  | √ | √ | √ |