Table 2 RAPID-CTCA trial exclusion criteria
1. Signs, symptoms or investigations supporting high-risk ACS | • ST elevation MI • ACS with signs or symptoms of acute heart failure • ACS with signs or symptoms of circulatory shock • Crescendo episodes of typical anginal pain • Marked or dynamic ECG changes, e.g. ST depression of >3 mm • Clinical team have scheduled early ICA on day of trial eligibility assessment |
2. Patient inability to undergo CT | • Severe renal failure (serum creatinine >250 μmol/L or estimated glomerular filtration rate <30 mL/min/1.73 m2) • Contrast allergy • Beta blocker intolerance or allergy (if no alternative heart rate-limiting agent available/suitable) • Inability to hold breath • Atrial fibrillation (where mean heart rate is anticipated to be greater than 75 beats/min after beta blockade) |
3. Patient had ICA or CTCA within the last 2 years revealing obstructive CAD or patient had ICA or CTCA within the last 5 years and the result was normal 4. Previous recruitment to the trial 5. Known pregnancy or currently breast feeding 6. Inability to consent 7. Further investigation for ACS would not be in the patient’s interest due to limited life expectancy, quality of life or functional status 8. Prisoners | |