Multipoint Pacing versus conventional ICD in Patients with a Narrow QRS complex (MPP Narrow QRS trial): study protocol for a pilot randomized controlled trial

Table 2 List of all investigational-specific activities/procedures

	Time point	Enrollment	Implant	Pre-discharge	6-12-24 month follow-up	Implant	6-12-24 month follow-up
	Study activity	ALL patients		MPP group		Standard ICD group
Enrollment	Low-dose dobutamine stress echocardiography	X
	Informed consent process	X
	Verification of inclusion/exclusion criteria	X
	Demographics and medical history	X
	Randomization	X
Intervention:	MPP device implant		X
Intervention:	Standard ICD implant					X
Assessment	Fluoro images and/or cine of venogram and final lead position, two projections		X			X
	Capture thresholds and signal amplitude measurements on RA and RV leads		X	X	X	X	X
	Capture thresholds and phrenic nerve stimulation occurrence at LV pacing configurations		X	X	X
	NYHA functional class	X			X		X
	QRS duration	X		X	X		X
	Standard echo measurements	X			X		X
	Electrical delay measurements			X	X
	QRS optimization			X	X
	12-lead ECG during QRS optimization			X	X
	Echo measurements and AV optimization			X	X
	Optimal programming of the device			X	X

MPP multipoint pacing, ICD implantable cardioverter defibrillator, RA right atrium, RV right ventricle, LV left ventricle NYHA New York Heart Association, ECG electrocardiogram, AV atrioventricular

ISSN: 1745-6215