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Table 1 Schedule of treatments and outcome measurements

From: Evaluation of the anti-fatigue effects of a traditional herbal drug, Gongjin-dan, under insufficient sleep conditions: study protocol for a randomised controlled trial

  1. aStress hormones; oxidative stress-related biomarkers: serum cortisol, epinephrine, norepinephrine; ROS, NO, MDA, protein carbonyl, GSH, GSH-Rx, SOD, catalase, TAC
  2. bImmunological factors: TNF-α, IFN-γ, IL-2, IL-10, IL-12, T cell, B cell, NK cell
  3. Evaluation at any time; 06:30 (30 min after waking up); 06:30 (30 min after waking up), 12:00 (before lunch), and 21:00; □ 15:00–17:00 (before dinner); 07:30–08:30, 12:10–13:00, and 17:30–18:30; ■ 18:30–21:00 (after dinner); 1 pill twice a day, 30 min before breakfast/dinner