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Table 2 Gradual interruption of baclofen or placebo after extubation or tracheotomy or on the 15th day of treatment

From: Baclofen to prevent agitation in alcohol-addicted patients in the ICU: study protocol for a randomised controlled trial

Dose administered on the day of extubation/tracheotomy/15th day

150 mg

100 mg

70 mg

50 mg

IHD 50 mg

Day +1

100 mg (20-30-50)

70 mg (20-20-30)

50 mg (10-20-20)

30 mg (10-10-10)

30 mg before dialysis (no administration if the patient is not dialysed)

Day +2

70 mg (20-20-30)

50 mg (10-20-20)

30 mg (10-10-10)

20 mg (10-0-10)

30 mg before dialysis (no administration if the patient is not dialysed)

Day +3

50 mg (10-20-20)

30 mg (10-10-10)

20 mg (10-0-10)

10 mg (10-0-0)

10 mg before dialysis (no administration if the patient is not dialysed)

Day +4

30 mg (10-10-10)

20 mg (10-0-10)

10 mg (10-0-0)

Stop

Stop

Day +5

20 mg (10-0-10)

10 mg (10-0-0)

Stop

  

Day +6

10 mg (10-0-)

Stop

   

Day +7

Stop

    
  1. IHD intermittent haemodialysis