| Enrolment | Allocation | Post allocation | |||
---|---|---|---|---|---|---|
Timepoint | ICU admission | Â | ICU stay (daily) | ICU discharge | Hospital discharge | 6-month follow-up |
Enrolment: | ||||||
 Eligibility screen | x |  |  |  |  |  |
 Consent by nonparticipating doctor | x |  |  |  |  |  |
 Allocation |  | x |  |  |  |  |
 Informed consent by proxy |  | ≤72 h |  |  |  |  |
Data collection: | ||||||
 Demographic and diagnostic data |  | x |  |  |  |  |
 APACHE II score | x |  |  |  |  |  |
 SOFA score |  |  | x |  |  |  |
 TISS 28 and 76 | x |  |  | x |  |  |
 Laboratory findings | x | x |  | x |  |  |
 Medication |  |  | x |  |  |  |
Physiotherapy Interventions: | ||||||
 Frequency, duration and content |  |  | x |  |  |  |
 Safety and physiological parameters |  |  | x |  |  |  |
 Mobility milestones |  |  | x |  |  |  |
 Bed rest complications |  |  | x |  |  |  |
 Serious/adverse events |  |  | x |  |  |  |
Outcome measures: | ||||||
 Muscle strength: MRC sum score, handgrip and quadriceps strength |  |  |  | x |  |  |
 Range of motion |  |  |  | x |  |  |
 Functional Independence Measure |  |  |  | x | x |  |
 Length of stay (ICU and hospital), days on mechanical ventilation |  |  |  |  | x |  |
 6-Minute Walk Test |  |  |  |  | x |  |
 Timed ‘Up & Go’ Test |  |  |  |  | x |  |
Short Form 36 | Â | Â | Â | Â | Â | x |