The Post-Anaesthesia N-acetylcysteine Cognitive Evaluation (PANACEA) trial: study protocol for a randomised controlled trial

Table 1 Timeline of instruments

Instruments	Recruitment	Prior to surgery	Day of surgery	POD2	POD7–14	3–4 months	12–13 months
MMSE^a	X
CBB^b		X			X	X	X
RBANS^b		X			X	X	X
COWAT^b		X			X	X	X
TMT^b		X			X	X	X
CAM^a				X	X
HADS^b		X			X	X	X
WHOQOL-BREF^b		X				X	X
NRS11^a		X		X	X
Modified Brief Pain Inventory^b						X
Neuropathic Pain Questionnaire^b							X
Research blood sample – biomarkers^a			X	X

A table with assessment and data collection types listed as rows, and data collection points in columns. The corresponding collection point for each assessment is marked with an ‘X’”. This conforms with the SPIRIT guidelines (Additional file 1)
CAM Confusion Assessment Method, CBB CogState Brief Battery, COWAT Controlled Oral Word Association Test, HADS Hospital Anxiety and Depression Scale, MMSE Mini Mental State Exam, NRS11 Numerical Rating Scale for Pain, POD postoperative day, RBANS Repeatable Battery for the Assessment of Neuropsychological Status, TMT Trail Making Tests A and B, WHOQOL-BREF World Health Organisation Quality of Life scale
^aTo be performed by trained research staff
^bTo be performed by research staff trained in the neuropsychological assessment

ISSN: 1745-6215